date: 2017-09-22T07:50:25Z
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pdf:docinfo:title: Human cerebellar sub-millimeter diffusion imaging reveals the motor and non-motor topography of the dentate nucleus
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subject: The reciprocal cortico-cerebellar loops that underlie cerebellar contributions to motor and cognitive behaviour form one of the largest systems in the primate brain. Work with non-human primates has shown that the dentate nucleus, the major output nucleus of the cerebellum, contains topographically distinct connections to both motor and non-motor regions, yet there is no evidence for how the cerebellar cortex connects to the dentate nuclei in humans. Here we used in-vivo submillimeter diffusion imaging to characterise this fundamental component of the cortico-cerebellar loop, and identified a pattern of superior motor and infero-lateral non-motor connectivity strikingly similar to that proposed by animal work. Crucially, we also present first evidence that the dominance for motor connectivity observed in non-human primates may be significantly reduced in man ? a finding that is in accordance with the proposed increase in cerebellar contributions to higher cognitive behaviour over the course of primate evolution.
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dc:title: Human cerebellar sub-millimeter diffusion imaging reveals the motor and non-motor topography of the dentate nucleus
modified: 2017-09-22T07:50:25Z
cp:subject: The reciprocal cortico-cerebellar loops that underlie cerebellar contributions to motor and cognitive behaviour form one of the largest systems in the primate brain. Work with non-human primates has shown that the dentate nucleus, the major output nucleus of the cerebellum, contains topographically distinct connections to both motor and non-motor regions, yet there is no evidence for how the cerebellar cortex connects to the dentate nuclei in humans. Here we used in-vivo submillimeter diffusion imaging to characterise this fundamental component of the cortico-cerebellar loop, and identified a pattern of superior motor and infero-lateral non-motor connectivity strikingly similar to that proposed by animal work. Crucially, we also present first evidence that the dominance for motor connectivity observed in non-human primates may be significantly reduced in man ? a finding that is in accordance with the proposed increase in cerebellar contributions to higher cognitive behaviour over the course of primate evolution.
pdf:docinfo:subject: The reciprocal cortico-cerebellar loops that underlie cerebellar contributions to motor and cognitive behaviour form one of the largest systems in the primate brain. Work with non-human primates has shown that the dentate nucleus, the major output nucleus of the cerebellum, contains topographically distinct connections to both motor and non-motor regions, yet there is no evidence for how the cerebellar cortex connects to the dentate nuclei in humans. Here we used in-vivo submillimeter diffusion imaging to characterise this fundamental component of the cortico-cerebellar loop, and identified a pattern of superior motor and infero-lateral non-motor connectivity strikingly similar to that proposed by animal work. Crucially, we also present first evidence that the dominance for motor connectivity observed in non-human primates may be significantly reduced in man ? a finding that is in accordance with the proposed increase in cerebellar contributions to higher cognitive behaviour over the course of primate evolution.
pdf:docinfo:creator: Christopher J. Steele, Alfred Anwander, Pierre-Louis Bazin, Robert Trampel, Andreas Schaefer, Robert Turner, Narender Ramnani, and Arno Villringer
meta:author: Christopher J. Steele, Alfred Anwander, Pierre-Louis Bazin, Robert Trampel, Andreas Schaefer, Robert Turner, Narender Ramnani, and Arno Villringer
meta:creation-date: 2017-09-22T07:50:25Z
created: 2017-09-22T07:50:25Z
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Creation-Date: 2017-09-22T07:50:25Z
Author: Christopher J. Steele, Alfred Anwander, Pierre-Louis Bazin, Robert Trampel, Andreas Schaefer, Robert Turner, Narender Ramnani, and Arno Villringer
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Keywords: cerebellum and cognition, cortico-cerebellar loop, dentate nucleus, motor and non-motor cerebellar white-matter connectivity
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dc:creator: Christopher J. Steele, Alfred Anwander, Pierre-Louis Bazin, Robert Trampel, Andreas Schaefer, Robert Turner, Narender Ramnani, and Arno Villringer
dcterms:created: 2017-09-22T07:50:25Z
Last-Modified: 2017-09-22T07:50:25Z
dcterms:modified: 2017-09-22T07:50:25Z
title: Human cerebellar sub-millimeter diffusion imaging reveals the motor and non-motor topography of the dentate nucleus
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pdf:docinfo:keywords: cerebellum and cognition, cortico-cerebellar loop, dentate nucleus, motor and non-motor cerebellar white-matter connectivity
pdf:docinfo:modified: 2017-09-22T07:50:25Z
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creator: Christopher J. Steele, Alfred Anwander, Pierre-Louis Bazin, Robert Trampel, Andreas Schaefer, Robert Turner, Narender Ramnani, and Arno Villringer
dc:language: en-US
dc:subject: cerebellum and cognition, cortico-cerebellar loop, dentate nucleus, motor and non-motor cerebellar white-matter connectivity
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meta:keyword: cerebellum and cognition, cortico-cerebellar loop, dentate nucleus, motor and non-motor cerebellar white-matter connectivity
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pdf:docinfo:created: 2017-09-22T07:50:25Z