Intracellular regulation of the insect chemoreceptor complex impacts odour 
localization in flying insects

Getahun, Merid Negash; Thoma, Michael; Lavista Llanos, Sofia; Keesey, Ian; Fandino, Richard A.; Knaden, Markus; Wicher, Dieter; Olsson, Shannon B.; Hansson, Bill S.

doi:10.1242/jeb.143396

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Intracellular regulation of the insect chemoreceptor complex impacts odour localization in flying insects

MPS-Authors

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Getahun, Merid Negash
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

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Thoma, Michael
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

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Lavista Llanos, Sofia
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Keesey, Ian
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Knaden, Markus
Research Group Dr. M. Knaden, Insect Behavior, Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Wicher, Dieter
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Olsson, Shannon B.
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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Hansson, Bill S.
Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society;

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http://dx.doi.org/10.1242/jeb.143396
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引用

Getahun, M. N., Thoma, M., Lavista Llanos, S., Keesey, I., Fandino, R. A., Knaden, M., Wicher, D., Olsson, S. B., & Hansson, B. S. (2016). Intracellular regulation of the insect chemoreceptor complex impacts odour localization in flying insects. Journal of Experimental Biology, 219, 3428-3438. doi:10.1242/jeb.143396.

引用: https://hdl.handle.net/11858/00-001M-0000-002B-2E66-B

要旨

Flying insects are well known for airborne odour tracking and have evolved diverse chemoreceptors. While ionotropic receptors (IRs) are
found across protostomes, insect odorant receptors (ORs) have only
been identified in winged insects. We therefore hypothesized that the
unique signal transduction of ORs offers an advantage for odour
localization in flight. Using Drosophila, we found expression and
increased activity of the intracellular signalling protein PKC in antennal
sensilla following odour stimulation. Odour stimulation also enhanced
phosphorylation of theORco-receptorOrco in vitro, while site-directed
mutation of Orco or mutations in PKC subtypes reduced the sensitivity
and dynamic range of OR-expressing neurons in vivo, but not
IR-expressing neurons. We ultimately show that these mutations
reduce competence for odour localization of flies in flight.We conclude
that intracellular regulation of OR sensitivity is necessary for efficient
odour localization, which suggests a mechanistic advantage for the
evolution of the OR complex in flying insects.