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Riccardo Metere, Tobias Kober, Harald E. Möller, Andreas Schäfer
Simultaneous Quantitative MRI Mapping of T1, T2* and Magnetic Susceptibility with Multi-Echo MP2RAGE
www.plosone.org
www.plosone.org
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4.6715 0 Td
(are)Tj
1.4513 0 Td
(properly)Tj
3.6284 0 Td
(chosen,)Tj
3.2371 0 Td
(allowing)Tj
3.617 0 Td
(for)Tj
1.389 0 Td
(sufficient)Tj
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5.0343 0 Td
(to)Tj
1.0261 0 Td
(inhomogeneities)Tj
6.8768 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
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7.1376 0 Td
(\(RF\))Tj
2.0466 0 Td
(transmit)Tj
3.6169 0 Td
(magnetic)Tj
3.9005 0 Td
(field)Tj
1.9728 0 Td
(ampli-)Tj
-34.0948 -1.2982 Td
(tude,)Tj
/F16 1 Tf
0 Tc
2.2223 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 227.9622 432.4535 cm
BT
/F3 1 Tf
1 TL
0 0 Td
()Tj
/F9 1 Tf
0 -1.0677 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 233.0645 428.8251 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(.)Tj
-2.1089 -1.3322 Td
(Mapping)Tj
3.8663 0 Td
(of)Tj
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0 Tc
1.0148 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 267.4204 419.1307 cm
BT
/F3 1 Tf
1 TL
0 0 Td
()Tj
/F9 1 Tf
-0.1133 -1.0677 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 273.1464 415.5023 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
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(requires)Tj
3.4695 0 Td
(a)Tj
0.6577 0 Td
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2.5739 0 Td
(times,)Tj
/F16 1 Tf
2.6135 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 257.7826 400.5921 cm
BT
/F16 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
/F10 1 Tf
(,)Tj
/F16 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 265.5496 402.2362 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(.)Tj
0.4478 0 Td
(Usually,)Tj
3.4526 0 Td
(the)Tj
1.4683 0 Td
(FLASH)Tj
3.2145 0 Td
(sequence)Tj
3.8551 0 Td
(with)Tj
1.9956 0 Td
(multi-echo)Tj
4.6147 0 Td
(\(ME\))Tj
2.3641 0 Td
(readout)Tj
3.3052 0 Td
(is)Tj
0.8504 0 Td
(employed)Tj
4.1385 0 Td
(for)Tj
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0 Tc
-36.2604 -1.2982 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 206.6456 392.8818 cm
BT
/F3 1 Tf
1 TL
0 0 Td
()Tj
/F9 1 Tf
-0.1133 -1.0677 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 210.1606 389.2535 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-related)Tj
3.2938 0 Td
(relaxometry,)Tj
5.2611 0 Td
(because)Tj
3.3221 0 Td
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1.0148 0 Td
(its)Tj
1.1452 0 Td
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3.8381 0 Td
(high)Tj
2.0069 0 Td
(robustness)Tj
4.4901 0 Td
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3.0274 0 Td
(inhomogeneities)Tj
6.8711 0 Td
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1.0148 0 Td
(the)Tj
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2.2902 0 Td
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3.8948 0 Td
(field)Tj
1.9729 0 Td
(amplitude,)Tj
/F16 1 Tf
4.5071 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 332.3905 374.2866 cm
BT
/F10 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 335.9622 375.9874 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
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(.)Tj
-12.3986 -1.3039 Td
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1.1112 0 Td
(recent)Tj
2.7099 0 Td
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2.4888 0 Td
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5.2157 0 Td
(Susceptibility)Tj
5.5558 0 Td
(Mapping)Tj
3.8607 0 Td
(\(QSM\))Tj
3.0161 0 Td
(has)Tj
1.542 0 Td
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4.2689 0 Td
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1.0262 0 Td
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3.3278 0 Td
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3.5717 0 Td
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(bulk)Tj
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3.9004 0 Td
(susceptibility,)Tj
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5.6636 0 Td
(!)Tj
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0.7313 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
3.5433 0 Td
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0.8561 0 Td
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-32.8022 -1.2983 Td
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2.3527 0 Td
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1.0148 0 Td
(the)Tj
1.4684 0 Td
(spatial)Tj
2.7779 0 Td
(variation)Tj
3.7984 0 Td
(of)Tj
/F16 1 Tf
1.0148 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 330.0094 335.2818 cm
BT
/F10 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 335.7354 336.9826 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(extracted)Tj
3.8891 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(signal)Tj
2.5455 0 Td
(phase)Tj
2.4832 0 Td
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1.0148 0 Td
(a)Tj
0.6519 0 Td
(GRE)Tj
2.126 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.0749 0 Td
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(anisotropy)Tj
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1.0148 0 Td
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5.4425 0 Td
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1.0148 0 Td
(micro-structural)Tj
6.8202 0 Td
(components)Tj
5.176 0 Td
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2.8459 0 Td
(to)Tj
1.0262 0 Td
(influence)Tj
3.9174 0 Td
(the)Tj
1.4683 0 Td
(phase)Tj
2.4832 0 Td
(contrast)Tj
3.4638 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
([)Tj
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(18)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(21)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
3.2088 0 Td
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5.6126 0 Td
(QSM)Tj
2.3357 0 Td
(has)Tj
1.542 0 Td
(led)Tj
1.4174 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
-34.9168 -1.2983 Td
(possibility)Tj
4.2746 0 Td
(of)Tj
1.0148 0 Td
(differentiating)Tj
5.9357 0 Td
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3.5262 0 Td
(diamagnetic)Tj
5.1306 0 Td
(myelin)Tj
2.9764 0 Td
(and)Tj
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(paramagnetic)Tj
5.6522 0 Td
(iron)Tj
1.9162 0 Td
(deposition)Tj
-32.1615 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7347 0 Td
(28)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(])Tj
2.9821 0 Td
(that)Tj
1.7744 0 Td
(is)Tj
0.8504 0 Td
(already)Tj
3.1125 0 Td
(exploited)Tj
3.8946 0 Td
(in)Tj
1.0375 0 Td
(brain)Tj
2.3471 0 Td
(research)Tj
3.5546 0 Td
(and)Tj
1.7291 0 Td
(clinical)Tj
3.0784 0 Td
(applications.)Tj
-24.8992 -1.2983 Td
(As)Tj
1.2699 0 Td
(a)Tj
0.6519 0 Td
(typical)Tj
2.863 0 Td
(drawback,)Tj
4.32 0 Td
(many)Tj
2.4775 0 Td
(techniques)Tj
4.5296 0 Td
(for)Tj
1.3833 0 Td
(quantitative)Tj
4.9776 0 Td
(mapping)Tj
3.7927 0 Td
(of)Tj
1.0148 0 Td
(tissue)Tj
2.4605 0 Td
(parameters)Tj
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(require)Tj
3.1124 0 Td
(longer)Tj
2.7779 0 Td
(scan)Tj
1.9899 0 Td
(times)Tj
2.3868 0 Td
(than)Tj
2.0296 0 Td
(conventional)Tj
/F16 1 Tf
5.4253 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 383.1307 257.2724 cm
BT
/F10 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 386.7023 258.9732 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-,)Tj
/F16 1 Tf
0 Tc
0.7993 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 401.3291 262.6015 cm
BT
/F3 1 Tf
1 TL
0 0 Td
()Tj
/F9 1 Tf
-0.1228 -1.0677 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 404.844 258.9732 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-)Tj
0.5669 0 Td
(or)Tj
1.0998 0 Td
(susceptibility-weighted)Tj
9.411 0 Td
(MR)Tj
1.7291 0 Td
(Imaging)Tj
-33.2898 -1.3266 Td
(\(MRI\).)Tj
2.9764 0 Td
(This)Tj
1.9899 0 Td
(imposes)Tj
3.4753 0 Td
(limitations)Tj
4.5354 0 Td
(in)Tj
1.0374 0 Td
(clinical)Tj
3.0728 0 Td
(studies)Tj
2.9877 0 Td
(where)Tj
2.6474 0 Td
(the)Tj
1.474 0 Td
(available)Tj
3.6624 0 Td
(scan)Tj
1.9899 0 Td
(time)Tj
2.0296 0 Td
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0.8447 0 Td
(often)Tj
-32.7229 -1.3039 Td
(restricted.)Tj
4.2123 0 Td
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3.0274 0 Td
(more)Tj
2.3414 0 Td
(versatile)Tj
3.5036 0 Td
(sequence)Tj
3.8551 0 Td
(implementations)Tj
7.0014 0 Td
(permitting)Tj
4.4957 0 Td
(the)Tj
1.4684 0 Td
(simultaneous)Tj
-29.9053 -1.2982 Td
(acquisition)Tj
4.6261 0 Td
(of)Tj
1.0148 0 Td
(image)Tj
2.6306 0 Td
(data)Tj
1.9162 0 Td
(with)Tj
1.9956 0 Td
(different)Tj
3.6566 0 Td
(contrasts)Tj
3.8211 0 Td
(are)Tj
1.4512 0 Td
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1.0148 0 Td
(interest.)Tj
3.4356 0 Td
(Previous)Tj
3.6907 0 Td
(work)Tj
2.279 0 Td
(has)Tj
1.5421 0 Td
(shown)Tj
2.8459 0 Td
(that)Tj
-35.9203 -1.2983 Td
(collecting)Tj
4.0706 0 Td
(multiple)Tj
3.5659 0 Td
(echoes)Tj
2.8857 0 Td
(in)Tj
1.0318 0 Td
(conventional)Tj
5.4311 0 Td
(`Magnetization-Prepared)Tj
10.2159 0 Td
(RApid)Tj
2.8403 0 Td
(Gradient)Tj
3.8041 0 Td
(Echo')Tj
-33.8454 -1.3039 Td
(\(MP-RAGE\))Tj
5.2894 0 Td
(imaging)Tj
3.4866 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(])Tj
1.8539 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(helpful)Tj
2.999 0 Td
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1.0318 0 Td
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(morphometry)Tj
5.8392 0 Td
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(33)Tj
0 g
(,)Tj
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1.7348 0 Td
(34)Tj
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(].)Tj
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(this)Tj
1.6724 0 Td
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(we)Tj
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4.1159 0 Td
(an)Tj
1.2019 0 Td
(ME)Tj
1.6838 0 Td
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1.0148 0 Td
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1.4683 0 Td
(MP2RAGE)Tj
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(sequence)Tj
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(3D)Tj
1.4287 0 Td
(map-)Tj
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(ping)Tj
2.0183 0 Td
(of)Tj
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1.0148 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 236.2393 165.9968 cm
BT
/F10 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 239.811 167.6976 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
/F16 1 Tf
0 Tc
0.4422 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 250.9228 171.3259 cm
BT
/F3 1 Tf
1 TL
0 0 Td
()Tj
/F9 1 Tf
-0.1228 -1.0677 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 254.3811 167.6976 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
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(,)Tj
0.4478 0 Td
(and)Tj
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1.7291 0 Td
(!)Tj
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(Computer)Tj
4.3483 0 Td
(simulations)Tj
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(and)Tj
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(experimental)Tj
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(verification)Tj
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1.0375 0 Td
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(human)Tj
-33.8964 -1.3322 Td
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2.7099 0 Td
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(7T)Tj
1.3039 0 Td
(demonstrate)Tj
5.2326 0 Td
(that)Tj
1.7802 0 Td
(all)Tj
1.1452 0 Td
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4.6714 0 Td
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1.6271 0 Td
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-34.0155 -1.2983 Td
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(separately)Tj
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3.702 0 Td
(MP2RAGE)Tj
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(ME-FLASH)Tj
5.0287 0 Td
(scans.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 112.9889 cm
BT
/F4 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(2)Tj
0.7653 0 Td
(Methods)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F10 1 Tf
1 TL
-0.004 Tc
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(In)Tj
1.1055 0 Td
(order)Tj
2.4207 0 Td
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(investigate)Tj
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(whether)Tj
3.4752 0 Td
(the)Tj
1.474 0 Td
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(mapping)Tj
3.7927 0 Td
(of)Tj
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1.0148 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 558.3685 94.337 cm
BT
/F10 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
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0 Tc
-36.1925 -1.2982 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 206.6456 86.6267 cm
BT
/F3 1 Tf
1 TL
0 0 Td
()Tj
/F9 1 Tf
-0.1133 -1.0677 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 212.3716 82.9984 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
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1.7291 0 Td
(!)Tj
/F10 1 Tf
(,)Tj
0.9524 0 Td
(we)Tj
1.3266 0 Td
(used)Tj
2.058 0 Td
(a)Tj
0.6576 0 Td
(twostep)Tj
3.8267 0 Td
(approach:)Tj
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4.1783 0 Td
[()]TJ
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1.1338 0 Td
(the)Tj
1.4684 0 Td
(effects)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
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1.4683 0 Td
(acquisition)Tj
4.6318 0 Td
(parameters)Tj
4.6715 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 394.4125 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Simultan)Tj
3.8197 0 Td
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