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Julia Tornack, Stephen T. Reece, Wolfgang M. Bauer, Alexis Vogelzang, Silke Bandermann, Ulrike Zedler, Georg Stingl, Stefan H. E. Kaufmann, Fritz Melchers
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis
www.plosone.org
www.plosone.org
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-0.004 Tc
0 0 Td
(CD45)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 397.4173 516.8692 cm
BT
/F16 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 403.8803 512.3905 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(MSCs)Tj
/F10 1 Tf
2.6135 0 Td
[(\n)12()]TJ
1.0148 0 Td
[()-13(\n)14()7( )20()]TJ
/F9 1 Tf
2.0409 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
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(equivalent)Tj
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(pop-)Tj
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(ulation)Tj
3.0501 0 Td
(of)Tj
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3.4072 0 Td
(MSCs)Tj
2.6136 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(mouse)Tj
2.863 0 Td
(may)Tj
1.9275 0 Td
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3.2881 0 Td
(a)Tj
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(long-term)Tj
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(niche)Tj
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1.0374 0 Td
(the)Tj
1.4627 0 Td
(host)Tj
1.9106 0 Td
(in)Tj
1.0318 0 Td
(which)Tj
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2.6475 0 Td
[()16()]TJ
/F9 1 Tf
1.8652 0 Td
(can)Tj
1.6214 0 Td
(reside)Tj
2.5908 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(24)Tj
0 g
(].)Tj
1.7348 0 Td
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1.7801 0 Td
(quiescence)Tj
4.541 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4627 0 Td
(hypoxic)Tj
3.3846 0 Td
(niche)Tj
2.4037 0 Td
(of)Tj
1.0148 0 Td
(mes-)Tj
-35.6425 -1.3039 Td
(enchymal)Tj
4.0989 0 Td
(and)Tj
1.7291 0 Td
(hematopoietic)Tj
5.93 0 Td
(cells)Tj
1.9219 0 Td
(could)Tj
2.4548 0 Td
(provide)Tj
3.2882 0 Td
(stress)Tj
2.3923 0 Td
(and)Tj
1.7348 0 Td
(induce)Tj
2.9367 0 Td
(dormancy)Tj
4.3086 0 Td
(genes)Tj
2.4378 0 Td
(of)Tj
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1.0148 0 Td
[()16()]TJ
/F9 1 Tf
-34.2479 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
1.1962 -1.2982 Td
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1.8709 0 Td
(findings)Tj
3.4922 0 Td
(suggest)Tj
3.1181 0 Td
(that)Tj
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1.7802 0 Td
[()16()]TJ
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(-infected)Tj
5.4198 0 Td
(bone)Tj
2.2053 0 Td
(marrow-derived)Tj
6.752 0 Td
(hematopoietic)Tj
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(cells)Tj
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(of)Tj
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(mice)Tj
2.1543 0 Td
(and)Tj
1.7291 0 Td
(humans,)Tj
3.6624 0 Td
(together)Tj
3.5376 0 Td
(with)Tj
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1.9956 0 Td
[()16()]TJ
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(-infected)Tj
5.4141 0 Td
(MSCs)Tj
2.6134 0 Td
(serve)Tj
2.2564 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
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(hitherto)Tj
3.4412 0 Td
(unappreciated)Tj
5.9357 0 Td
(cellular)Tj
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(niche)Tj
2.4094 0 Td
(during)Tj
2.9254 0 Td
(LTBI,)Tj
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(capable)Tj
3.2032 0 Td
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1.0148 0 Td
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5.2667 0 Td
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2.5228 0 Td
(TB)Tj
1.4116 0 Td
(disease.)Tj
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3.2428 0 Td
[()16()]TJ
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5.6409 0 Td
(blood-borne)Tj
5.2214 0 Td
(LT-)Tj
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(can)Tj
1.6271 0 Td
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1.1508 0 Td
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1.7347 0 Td
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1.0205 0 Td
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3.5432 0 Td
(drug)Tj
2.109 0 Td
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4.7224 0 Td
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3.8551 0 Td
(chal-)Tj
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2.6872 0 Td
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3.1862 0 Td
(hypotheses)Tj
4.6204 0 Td
(of)Tj
1.0148 0 Td
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(pathogenesis)Tj
5.3518 0 Td
(and)Tj
1.7291 0 Td
(epidemiology.)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 366.0094 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
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/F0 1 Tf
0 -1.5023 Td
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3.4063 0 Td
(peripheral)Tj
4.6016 0 Td
(blood)Tj
2.6268 0 Td
(SP)Tj
ET
Q
q
1 j
1 J
0 w
8.9997 0 0 7.999 343.559 353.3102 cm
BT
/F0 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 351.3826 347.9811 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(and)Tj
1.8661 0 Td
(Lin)Tj
ET
Q
q
1 j
1 J
0 w
8.9997 0 0 7.999 389.537 353.3102 cm
BT
/F0 1 Tf
1 TL
-0.0044 Tc
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 394.4125 347.9811 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(CD34)Tj
ET
Q
q
1 j
1 J
0 w
8.9997 0 0 7.999 424.7433 353.3102 cm
BT
/F0 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 429.959 347.9811 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(CD90)Tj
ET
Q
q
1 j
1 J
0 w
8.9997 0 0 7.999 460.2897 353.3102 cm
BT
/F0 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 465.4488 347.9811 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(CD38)Tj
ET
Q
q
1 j
1 J
0 w
8.9997 0 0 7.999 495.7795 353.3102 cm
BT
/F0 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(lo)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 505.2472 347.9811 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(pHSCs)Tj
3.359 0 Td
(of)Tj
-28.7954 -1.1669 Td
(IGRA)Tj
ET
Q
q
1 j
1 J
0 w
8.9997 0 0 7.999 229.2094 339.307 cm
BT
/F0 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 237.033 333.9779 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(donors)Tj
3.2409 0 Td
(carry)Tj
/F8 1 Tf
2.4189 0 Td
(Mtb)Tj
/F0 1 Tf
1.8756 0 Td
(DNA)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 317.0267 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(We)Tj
1.61 0 Td
(searched)Tj
3.7077 0 Td
(for)Tj
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1.389 0 Td
[()16()]TJ
/F9 1 Tf
1.8652 0 Td
(DNA)Tj
2.3754 0 Td
(in)Tj
1.0375 0 Td
(human)Tj
3.0784 0 Td
(pHSCs)Tj
3.0047 0 Td
(of)Tj
1.0148 0 Td
(donors)Tj
3.0387 0 Td
(with)Tj
2.0012 0 Td
(LTBI.)Tj
2.5115 0 Td
(To)Tj
1.338 0 Td
(this)Tj
1.6781 0 Td
(end)Tj
1.7177 0 Td
(we)Tj
1.3266 0 Td
(purified)Tj
-32.6945 -1.3039 Td
(Lin)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 213.5622 308.4661 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 217.4173 303.9874 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(CD34)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 240.9448 308.4661 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 247.4645 303.9874 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
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(progenitors,)Tj
5.0796 0 Td
(and)Tj
1.7348 0 Td
(within)Tj
2.8119 0 Td
(them)Tj
2.2904 0 Td
(Lin)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 380.1259 308.4661 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 384.0377 303.9874 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(CD34)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 407.5086 308.4661 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 411.874 303.9874 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(CD90)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 435.4015 308.4661 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 439.7102 303.9874 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(CD38)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 463.2377 308.4661 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(-)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 468.0566 303.9874 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(pHSCs)Tj
3.0047 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1A)Tj
2.194 0 Td
(Fig)Tj
0 g
(\),)Tj
2.0466 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
-35.0643 -1.2982 Td
(as,)Tj
1.2416 0 Td
(CD1c)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 235.3889 295.4267 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 241.9086 291.0047 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(dendritic)Tj
3.8777 0 Td
(cells,)Tj
2.143 0 Td
(CD14)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 325.644 295.4267 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 330.0094 291.0047 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(CD16)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 353.4803 295.4267 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(low)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 366.4629 291.0047 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7291 0 Td
(CD14)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 407.2251 295.4267 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(low)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 417.9968 291.0047 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(CD16)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 441.5244 295.4267 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(monocytes,)Tj
4.7905 0 Td
(CD15)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 519.4204 295.4267 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 525.9968 291.0047 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(granulo-)Tj
-32.5982 -1.2982 Td
(cytes,)Tj
2.4038 0 Td
(CD4)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 242.8157 282.444 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 249.3354 278.022 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(or)Tj
1.0998 0 Td
(CD8)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 279.0992 282.444 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 285.6188 278.022 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(T)Tj
0.8333 0 Td
(cells,)Tj
2.143 0 Td
(CD19)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 338.9102 282.444 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 345.4299 278.022 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(cells)Tj
1.9218 0 Td
(identifying)Tj
4.5751 0 Td
(B)Tj
0.7994 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(dendritic)Tj
3.8778 0 Td
(cells)Tj
1.9219 0 Td
(and)Tj
1.7291 0 Td
(CD56)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 555.6472 282.444 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 264.9826 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(NK)Tj
1.627 0 Td
(cells)Tj
1.9219 0 Td
(by)Tj
1.1792 0 Td
(FACS)Tj
2.5739 0 Td
(from)Tj
2.2053 0 Td
(blood)Tj
2.5171 0 Td
(of)Tj
1.0148 0 Td
(IGRA)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 353.9905 269.4614 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 360.5102 264.9826 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7347 0 Td
(IGRA)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 401.4425 269.4614 cm
BT
/F16 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 405.6944 264.9826 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(donors)Tj
3.0443 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
(We)Tj
1.6101 0 Td
(also)Tj
1.7688 0 Td
(isolated)Tj
3.2825 0 Td
(pHSCs)Tj
-34.3159 -1.2982 Td
(by)Tj
1.1792 0 Td
(their)Tj
2.109 0 Td
(drug)Tj
2.1146 0 Td
(efflux)Tj
2.4548 0 Td
(properties)Tj
4.2803 0 Td
(as)Tj
1.0148 0 Td
(Hoechst)Tj
3.5262 0 Td
(low/)Tj
1.9899 0 Td
(negative)Tj
3.5319 0 Td
(side)Tj
1.8028 0 Td
(population)Tj
4.5864 0 Td
(\(SP\))Tj
1.9389 0 Td
(phenotype)Tj
4.4334 0 Td
(cells)Tj
-34.9622 -1.2983 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1A)Tj
2.194 0 Td
(Fig)Tj
0 g
(\),)Tj
2.0466 0 Td
(since)Tj
2.245 0 Td
(pHSCs)Tj
3.0047 0 Td
(are)Tj
1.4457 0 Td
(highly)Tj
2.7099 0 Td
(enriched)Tj
3.7304 0 Td
(in)Tj
1.0374 0 Td
(SP)Tj
1.2529 0 Td
(cells)Tj
1.9218 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(29)Tj
0 g
(].)Tj
1.7405 0 Td
(DNA)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1452 0 Td
(these)Tj
2.2563 0 Td
(potentially)Tj
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-31.8554 -1.3039 Td
[()16()]TJ
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(-infected)Tj
5.4141 0 Td
(cells)Tj
1.9219 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0262 0 Td
(PCR-amplify)Tj
5.4424 0 Td
(DNA)Tj
2.3755 0 Td
(fragments)Tj
4.2291 0 Td
(of)Tj
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1.0148 0 Td
[()16()]TJ
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(-encoded)Tj
5.5956 0 Td
(sequences)Tj
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Q
q
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Q
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Q
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q
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Q
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Q
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Q
q
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Q
q
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Q
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Q
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7.4999 0 0 6.6659 426.1606 337.6062 cm
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ET
Q
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Q
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Q
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(\()Tj
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Q
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1 j
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7.4999 0 0 6.6659 562.2803 337.6062 cm
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Q
q
1 j
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Q
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1 TL
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ET
Q
q
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1 J
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1 TL
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Q
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Q
q
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7.4999 0 0 6.6659 268.7811 298.6015 cm
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7.4999 0 0 6.6659 451.7291 298.6015 cm
BT
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1 TL
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(3)Tj
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Q
q
1 j
1 J
0 w
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1 TL
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ET
Q
q
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1 TL
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ET
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1 J
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7.4999 0 0 6.6659 399.9685 259.5968 cm
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1 TL
-0.0053 Tc
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(-)Tj
ET
Q
q
1 j
1 J
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(SP)Tj
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Q
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7.4999 0 0 6.6659 412.9511 259.5968 cm
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(CD34)Tj
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Q
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7.4999 0 0 6.6659 460.2897 259.5968 cm
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ET
Q
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1 J
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1 TL
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7.4999 0 0 6.6659 555.307 259.5968 cm
BT
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1 TL
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ET
Q
q
1 j
1 J
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1 TL
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Q
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7.4999 0 0 6.6659 260.9007 246.6141 cm
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1 TL
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()Tj
ET
Q
q
1 j
1 J
0 w
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BT
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1 TL
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(CD34)Tj
ET
Q
q
1 j
1 J
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7.4999 0 0 6.6659 288.2834 246.6141 cm
BT
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1 TL
-0.0053 Tc
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ET
Q
q
1 j
1 J
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BT
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1 TL
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(CD90)Tj
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Q
q
1 j
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7.4999 0 0 6.6659 316.1196 246.6141 cm
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1 TL
-0.0053 Tc
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ET
Q
q
1 j
1 J
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BT
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(CD38)Tj
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Q
q
1 j
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7.4999 0 0 6.6659 344.0125 246.6141 cm
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1 TL
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Q
q
1 j
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1 TL
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(as)Tj
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Q
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7.4999 0 0 6.6659 447.874 246.6141 cm
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1 TL
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ET
Q
q
1 j
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BT
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(CD45)Tj
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Q
q
1 j
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7.4999 0 0 6.6659 475.7102 246.6141 cm
BT
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1 TL
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ET
Q
q
1 j
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1 TL
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-35.1323 -1.3039 Td
(ried)Tj
/F10 1 Tf
1.8085 0 Td
[()16()]TJ
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1.8652 0 Td
(DNA)Tj
2.3754 0 Td
(while)Tj
2.3697 0 Td
(their)Tj
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(Lin)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 362.0409 233.6314 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 368.5606 229.1527 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(cells)Tj
1.9218 0 Td
(were)Tj
2.1203 0 Td
(consistently)Tj
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4.9606 0 Td
[()16()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 475.0299 233.6314 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(.)Tj
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(can)Tj
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(colonies)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 320.9385 207.6094 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 327.6283 203.1874 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
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(donors)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 480.6425 194.6267 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 486.5385 190.148 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(Lin)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 500.485 194.6267 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 504.4535 190.148 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD34)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 528.4913 194.6267 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 535.1811 190.148 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(and)Tj
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(Lin)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 213.9023 181.5874 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 217.9275 177.1653 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD34)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 241.9653 181.5874 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 246.444 177.1653 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD90)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 270.4818 181.5874 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 274.9039 177.1653 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD38)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 298.9417 181.5874 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(-)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 303.874 177.1653 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
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(pHSCs)Tj
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(isolated)Tj
3.3902 0 Td
(from)Tj
2.2564 0 Td
(two)Tj
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(of)Tj
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(the)Tj
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(donors,)Tj
3.3618 0 Td
(which,)Tj
2.9537 0 Td
(in)Tj
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(the)Tj
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1.508 0 Td
[()14()]TJ
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(PCR)Tj
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(assays,)Tj
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(contained)Tj
4.3143 0 Td
(between)Tj
3.6169 0 Td
(one)Tj
1.7405 0 Td
(and)Tj
1.7688 0 Td
(five)Tj
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1.7064 0 Td
[()16()]TJ
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1.9049 0 Td
(DNA)Tj
2.4151 0 Td
(copies)Tj
2.7949 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8766 0 Td
(1A1F)Tj
0 g
(\).)Tj
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(potentially)Tj
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(only)Tj
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1.7348 0 Td
(of)Tj
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1.7065 0 Td
[()16()]TJ
/F9 1 Tf
1.9048 0 Td
(DNA)Tj
2.4151 0 Td
(copies)Tj
2.7949 0 Td
(detected)Tj
3.6736 0 Td
(in)Tj
1.0602 0 Td
(Lin)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 377.2913 155.622 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 381.2598 151.1433 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD34)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 405.2976 155.622 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 411.9874 151.1433 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(and)Tj
1.7688 0 Td
(Lin)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 443.5653 155.622 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 447.5905 151.1433 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD34)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 471.6283 155.622 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 476.107 151.1433 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD90)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 500.1448 155.622 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 504.5669 151.1433 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD38)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 528.6047 155.622 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(-)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 533.537 151.1433 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(cells)Tj
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(was)Tj
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(replication-competent,)Tj
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(the)Tj
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(majority)Tj
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(quiescent)Tj
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(hematopoietic)Tj
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(cells.)Tj
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2.2564 0 Td
(lysates)Tj
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(of)Tj
1.0375 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 329.3858 129.6 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 335.2818 125.1779 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD271)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 364.1952 129.6 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 368.6173 125.1779 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD45)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 392.6551 129.6 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(-)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 397.5874 125.1779 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(MSCs)Tj
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(no)Tj
1.3039 0 Td
(CFUs)Tj
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(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8709 0 Td
(1F)Tj
0 g
(\).)Tj
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(donors)Tj
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(tested)Tj
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(the)Tj
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(majority)Tj
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(of)Tj
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[()16()]TJ
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(DNA)Tj
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(copies)Tj
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(detected)Tj
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(in)Tj
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(CD271)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 538.696 116.6173 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 543.1181 112.1385 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(CD45)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 567.1559 116.6173 cm
BT
/F9 1 Tf
1 TL
0.012 Tc
0 0 Td
(-)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 99.1559 cm
BT
/F9 1 Tf
1 TL
0.009 Tc
0 0 Td
(MSCs)Tj
2.6645 0 Td
(cells)Tj
1.9842 0 Td
(were)Tj
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(similarly)Tj
3.8041 0 Td
(not)Tj
1.6101 0 Td
(replication-competent.)Tj
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Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 703.8893 m
576 703.8893 l
576 703.3893 l
36 703.3893 l
f*
104.6273 703.3893 m
104.6273 690.3893 l
104.1273 690.8893 l
104.1273 703.3893 l
f*
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f*
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182.4849 690.3893 l
181.9848 690.8893 l
181.9848 703.3893 l
f*
182.4849 690.3893 m
104.6273 690.3893 l
104.6273 690.8893 l
181.9848 690.8893 l
f*
259.4285 703.3893 m
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258.9284 690.8893 l
258.9284 703.3893 l
f*
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258.9284 690.8893 l
f*
342.1871 703.3893 m
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341.6871 690.8893 l
341.6871 703.3893 l
f*
342.1871 690.3893 m
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341.6871 690.8893 l
f*
462.0081 703.3893 m
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f*
462.0081 690.3893 m
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f*
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f*
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f*
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f*
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181.9848 678.3894 l
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f*
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f*
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f*
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f*
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f*
342.1871 665.3894 m
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f*
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f*
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f*
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f*
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f*
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f*
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