Optical control of GIRK channels using visible light

Trads, Julie B.; Burgstaller, Jessica; Laprell, Laura; Konrad, David B.; de la Osa de la Rosa, Luis; Weaver, C. David; Baier, Herwig; Trauner, Dirk; Barber, David M.

doi:10.1039/c6ob02153k

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Optical control of GIRK channels using visible light

MPS-Authors

/persons/resource/persons192246

Burgstaller, Jessica
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons39224

Baier, Herwig
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

External Resource

http://pubs.rsc.org/en/content/articlehtml/2017/ob/c6ob02153k
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Trads, J. B., Burgstaller, J., Laprell, L., Konrad, D. B., de la Osa de la Rosa, L., Weaver, C. D., et al. (2017). Optical control of GIRK channels using visible light. Organic & Biomolecular Chemistry, 15(1), 76-81. doi:10.1039/c6ob02153k.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-651A-2

Abstract

G-protein coupled inwardly rectifying potassium (GIRK) channels are an integral part of inhibitory signal transduction pathways, reducing the activity of excitable cells via hyperpolarization. They play crucial roles in processes such as cardiac output, cognition and the coordination of movement. Therefore, the precision control of GIRK channels is of critical importance. Here, we describe the development of the azobenzene containing molecule VLOGO (Visible Light Operated GIRK channel Opener), which activates GIRK channels in the dark and is promptly deactivated when illuminated with green light. VLOGO is a valuable addition to the existing tools for the optical control of GIRK channels as it circumvents the need to use potentially harmful UV irradiation. We therefore believe that VLOGO will be a useful research tool for studying GIRK channels in biological systems.