Functional implications of Neandertal introgression in modern humans

Dannemann, Michael; Prüfer, Kay; Kelso, Janet

doi:10.1186/s13059-017-1181-7

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Functional implications of Neandertal introgression in modern humans

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Dannemann, Michael
The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Prüfer, Kay
Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Kelso, Janet
The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Dannemann_Functional_GenBio_2017.pdf
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引用

Dannemann, M., Prüfer, K., & Kelso, J. (2017). Functional implications of Neandertal introgression in modern humans. Genome Biology, 18:. doi:10.1186/s13059-017-1181-7.

引用: https://hdl.handle.net/11858/00-001M-0000-002D-084D-C

要旨

Admixture between early modern humans and Neandertals approximately 50,000–60,000 years ago has resulted in 1.5–4% Neandertal ancestry in the genomes of present-day non-Africans. Evidence is accumulating that some of these archaic alleles are advantageous for modern humans, while others are deleterious; however, the major mechanism by which these archaic alleles act has not been fully explored.