Structural reorganization of the chromatin remodeling enzyme Chd1 upon 
engagement with nucleosomes

Sundaramoorthy, Ramasubramanian; Hughes, Amanda L.; Singh, Vijender; Wiechens, Nicola; Ryan, Daniel P.; El-Mkami, Hassane; Petoukhov, Maxim; Svergun, Dmitri I.; Treutlein, Barbara; Quack, Salina; Fischer, Monika; Michaelis, Jens; Böttcher, Bettina; Norman, David G.; Owen-Hughes, Tom

doi:10.7554/eLife.22510

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Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

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Treutlein, Barbara
Single Cell Genomics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Sundaramoorthy_Structural_eLife_2017.pdf
(出版社版), 6MB

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Sundaramoorthy_Structural_eLife_2017_Suppl.pdf
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引用

Sundaramoorthy, R., Hughes, A. L., Singh, V., Wiechens, N., Ryan, D. P., El-Mkami, H., Petoukhov, M., Svergun, D. I., Treutlein, B., Quack, S., Fischer, M., Michaelis, J., Böttcher, B., Norman, D. G., & Owen-Hughes, T. (2017). Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes. eLife, 6:. doi:10.7554/eLife.22510.

引用: https://hdl.handle.net/11858/00-001M-0000-002D-3466-4

要旨

Structural models of the chromatin remodeling enzyme Chd1 in solution and when bound to chromatin indicate that conformational changes to both the enzyme and the nucleosome occur upon nucleotide dependent engagement.