Regulation of calcium influx by second messengers in rat mast cells

Penner, R.; Matthews, G.; Neher, E.

doi:10.1038/334499a0

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Regulation of calcium influx by second messengers in rat mast cells

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Penner, R.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Matthews, G.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Neher, E.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Penner, R., Matthews, G., & Neher, E. (1988). Regulation of calcium influx by second messengers in rat mast cells. Nature, 334(6182), 499-504. doi:10.1038/334499a0.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-4CC6-5

Abstract

Biphasic increases in the free intracellular calcium concentration, consisting of a large initial transient followed by a sustained elevation, are frequently observed in non-excitable cells following stimulation. In rat peritoneal mast cells a cAMP- and Ca-activated chloride current can interact with IP3-dependent calcium influx to provide the sustained elevation of intracellular Ca concentration following transient IP3-induced release of calcium from intracellular stores. This novel combination of second messenger systems provides a flexible means to modulate calcium-dependent processes such as exocytosis.