Variability and order in cytoskeletal dynamics of motile amoeboid cells

Hsu, Hsin-Fang; Bodenschatz, Eberhard; Westendorf, Christian; Gholami, Azam; Pumir, Alain; Tarantola, Marco; Beta, Carsten

doi:10.1103/PhysRevLett.119.148101

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Variability and order in cytoskeletal dynamics of motile amoeboid cells

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Hsu, Hsin-Fang
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Bodenschatz, Eberhard
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173707

Westendorf, Christian
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173518

Gholami, Azam
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons173623

Pumir, Alain
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Tarantola, Marco
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

/persons/resource/persons21364

Beta, Carsten
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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引用

Hsu, H.-F., Bodenschatz, E., Westendorf, C., Gholami, A., Pumir, A., Tarantola, M., & Beta, C. (2017). Variability and order in cytoskeletal dynamics of motile amoeboid cells. Physical Review Letters, 119(14):. doi:10.1103/PhysRevLett.119.148101.

引用: https://hdl.handle.net/11858/00-001M-0000-002E-0E6F-E

要旨

The chemotactic motion of eukaryotic cells such as leukocytes or metastatic cancer cells relies on membrane protrusions driven by the polymerization and depolymerization of actin. Here we show that the response of the actin system to a receptor stimulus is subject to a threshold value that varies strongly from cell to cell. Above the threshold, we observe pronounced cell-to-cell variability in the response amplitude. The polymerization time, however, is almost constant over the entire range of response amplitudes, while the depolymerization time increases with increasing amplitude. We show that cell-to-cell variability in the response amplitude correlates with the amount of Arp2/3, a protein that enhances actin polymerization. A time-delayed feedback model for the cortical actin concentration is consistent with all our observations and confirms the role of Arp2/3 in the observed cell-to-cell variability. Taken together, our observations highlight robust regulation of the actin response that enables a reliable timing of cell movement.