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Macarena Beigier-Bompadre, Georgina N. Montagna, Anja A. Kühl, Laura Lozza, January Weiner, Andreas Kupz, Alexis Vogelzang, Hans-Joachim Mollenkopf, Delia Löwe, Silke Bandermann, Anca Dorhoi, Volker Brinkmann, Kai Matuschewski, Stefan H. E. Kaufmann
Mycobacterium tuberculosis infection modulates adipose tissue biology
www.plospathogens.org
www.plospathogens.org
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447.0236 211.9181 m
472.3654 211.9181 l
h
f*
414.822 198.9354 m
444.926 198.9354 l
h
f*
440.9575 185.8961 m
450.4252 185.8961 l
h
f*
504.2835 185.8961 m
513.7512 185.8961 l
h
f*
518.2299 185.8961 m
527.7543 185.8961 l
h
f*
401.8961 146.948 m
428.0882 146.948 l
h
f*
279.1559 94.9039 m
306.085 94.9039 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(to)Tj
1.0261 0 Td
(uninfected)Tj
4.4957 0 Td
(animals.)Tj
3.5546 0 Td
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3.1691 0 Td
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1.3266 0 Td
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(Mtb-specific)Tj
5.2384 0 Td
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3.2428 0 Td
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Q
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7.4999 0 0 6.6659 479.9055 711.8362 cm
BT
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ET
Q
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BT
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(tissue)Tj
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1 TL
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(\()Tj
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(Fig)Tj
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(1A,)Tj
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(1B)Tj
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(and)Tj
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(determine)Tj
4.32 0 Td
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3.4809 0 Td
(Mtb)Tj
1.9162 0 Td
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(adipocytes)Tj
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(4)Tj
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(6)Tj
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(absence)Tj
3.3391 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(cell-impermeable)Tj
7.1659 0 Td
(antibiotic)Tj
4.0365 0 Td
(amikacin.)Tj
4.1329 0 Td
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2.2167 0 Td
(time,)Tj
2.2564 0 Td
(numbers)Tj
3.7757 0 Td
(of)Tj
1.0148 0 Td
(CFUs)Tj
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(remained)Tj
-32.9327 -1.2983 Td
(constant)Tj
3.6339 0 Td
(indicating)Tj
4.2633 0 Td
(that)Tj
1.7688 0 Td
(Mtb)Tj
1.9162 0 Td
(did)Tj
1.5364 0 Td
(not)Tj
1.5647 0 Td
(replicate)Tj
3.6227 0 Td
(inside)Tj
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(adipocytes)Tj
4.4277 0 Td
(\()Tj
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(Fig)Tj
1.8199 0 Td
(1D,)Tj
1.6497 0 Td
(1E)Tj
1.2586 0 Td
(and)Tj
1.7234 0 Td
(1F)Tj
0 g
(\),)Tj
1.7859 0 Td
(again)Tj
2.364 0 Td
(cor-)Tj
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4.4957 0 Td
(previous)Tj
3.651 0 Td
(findings)Tj
3.4922 0 Td
([)Tj
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(5)Tj
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(].)Tj
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3.1351 0 Td
(persistence)Tj
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1.474 0 Td
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2.6192 0 Td
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(conditions)Tj
4.4731 0 Td
([)Tj
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(22)Tj
0 g
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(Mtb)Tj
1.9162 0 Td
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3.685 0 Td
(dormant)Tj
3.7247 0 Td
(and)Tj
1.7348 0 Td
(expresses)Tj
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(a)Tj
0.6576 0 Td
(specific)Tj
3.1861 0 Td
(gene)Tj
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(the)Tj
1.4683 0 Td
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(survival)Tj
3.3392 0 Td
(regulon)Tj
3.3109 0 Td
(\()Tj
/F14 1 Tf
[()4()7()]TJ
/F9 1 Tf
(,)Tj
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2.6645 0 Td
[()44()]TJ
/F9 1 Tf
(\))Tj
3.8154 0 Td
([)Tj
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(23)Tj
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(,)Tj
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1.7405 0 Td
(24)Tj
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2.5682 0 Td
(genes)Tj
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(include)Tj
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3.1862 0 Td
[()10()]TJ
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[()44()]TJ
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(lysine)Tj
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(markers)Tj
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(26)Tj
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(].)Tj
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(Mtb-infected)Tj
5.4708 0 Td
(human)Tj
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[()4()7()]TJ
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(and)Tj
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1.7291 0 Td
[(\r)4()22()]TJ
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(\()Tj
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(Fig)Tj
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(1G)Tj
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(\))Tj
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(3T3-L1,)Tj
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3.3732 0 Td
[()4()7()]TJ
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(and)Tj
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-34.5994 -1.2983 Td
[()10()]TJ
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2.1656 0 Td
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2.1203 0 Td
(induced)Tj
3.4639 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1H)Tj
0 g
(\).)Tj
2.0295 0 Td
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1.6101 0 Td
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1.7801 0 Td
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1.0374 0 Td
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5.4425 0 Td
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1.0262 0 Td
(dormancy)Tj
4.3086 0 Td
(and)Tj
1.7291 0 Td
(conclude)Tj
3.8438 0 Td
(that)Tj
-34.8659 -1.3039 Td
(Mtb)Tj
1.9162 0 Td
(is)Tj
0.8503 0 Td
(internalized)Tj
4.989 0 Td
(by)Tj
1.1792 0 Td
(human)Tj
3.0784 0 Td
(and)Tj
1.7291 0 Td
(mouse)Tj
2.8573 0 Td
(adipocytes)Tj
4.4391 0 Td
(where)Tj
2.6475 0 Td
(it)Tj
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(from)Tj
2.2053 0 Td
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-33.8454 -1.2983 Td
(becomes)Tj
3.685 0 Td
(stressed.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 360 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(After)Tj
2.3149 0 Td
(aerosol)Tj
3.4536 0 Td
(infection)Tj
3.8977 0 Td
(of)Tj
1.0441 0 Td
(mice)Tj
2.3102 0 Td
(Mtb)Tj
1.8756 0 Td
(resides)Tj
3.4016 0 Td
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0.9827 0 Td
(perigonadal)Tj
5.367 0 Td
(fat)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 342.9921 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(We)Tj
1.61 0 Td
(next)Tj
1.9559 0 Td
(evaluated)Tj
3.9855 0 Td
(whether)Tj
3.4809 0 Td
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1.9162 0 Td
(resides)Tj
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(in)Tj
1.0375 0 Td
(adipose)Tj
3.2541 0 Td
(tissue)Tj
2.4605 0 Td
(after)Tj
2.0353 0 Td
(aerosol)Tj
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(infection)Tj
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(mice.)Tj
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(these)Tj
2.2506 0 Td
(experiments)Tj
5.1421 0 Td
(we)Tj
1.3266 0 Td
(evaluated)Tj
3.9911 0 Td
(the)Tj
1.4684 0 Td
(Mtb-CFUs)Tj
4.558 0 Td
(present)Tj
3.1635 0 Td
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1.0318 0 Td
(the)Tj
1.474 0 Td
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2.6079 0 Td
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4.9606 0 Td
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1.2415 0 Td
(pad,)Tj
1.9219 0 Td
(which)Tj
-35.138 -1.2983 Td
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1.6951 0 Td
(extensively)Tj
4.5864 0 Td
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3.1804 0 Td
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1.0262 0 Td
(exclude)Tj
3.2541 0 Td
(possible)Tj
3.4129 0 Td
(blood)Tj
2.5115 0 Td
(contamination.)Tj
6.3496 0 Td
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5.0059 0 Td
(fat)Tj
1.2359 0 Td
(pad)Tj
1.7008 0 Td
(was)Tj
1.7008 0 Td
(eval-)Tj
-35.6596 -1.3039 Td
(uated)Tj
2.4321 0 Td
(because)Tj
3.3165 0 Td
(obesity)Tj
3.0387 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.0579 0 Td
(reported)Tj
3.6624 0 Td
(its)Tj
1.1452 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
2.0012 0 Td
(insulin)Tj
2.9877 0 Td
(resistance)Tj
4.1272 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(28)Tj
0 g
(].)Tj
1.7348 0 Td
(At)Tj
-35.858 -1.2983 Td
(14)Tj
1.1678 0 Td
(and)Tj
1.7348 0 Td
(28)Tj
1.1679 0 Td
(days)Tj
1.9956 0 Td
(post-infection,)Tj
6.0547 0 Td
(CFUs)Tj
2.5058 0 Td
(of)Tj
1.0148 0 Td
(Mtb)Tj
1.9219 0 Td
(were)Tj
2.1203 0 Td
(not)Tj
1.5761 0 Td
(only)Tj
1.9729 0 Td
(detected)Tj
3.5659 0 Td
(in)Tj
1.0375 0 Td
(lung)Tj
2.0069 0 Td
(and)Tj
1.7291 0 Td
(spleen)Tj
2.744 0 Td
(but)Tj
1.5533 0 Td
(also)Tj
-35.8693 -1.2982 Td
(in)Tj
1.0318 0 Td
(perigonadal)Tj
4.9662 0 Td
(fat)Tj
1.2359 0 Td
(of)Tj
1.0148 0 Td
(infected)Tj
3.4242 0 Td
(mice)Tj
2.1544 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(2A)Tj
0 g
(\).)Tj
1.9446 0 Td
(These)Tj
2.5681 0 Td
(organs)Tj
2.9027 0 Td
(also)Tj
1.7688 0 Td
(harbored)Tj
3.8891 0 Td
(Mtb)Tj
1.9219 0 Td
(at)Tj
0.9524 0 Td
(56)Tj
1.1679 0 Td
(and)Tj
1.7291 0 Td
(90)Tj
1.1735 0 Td
(days)Tj
-35.6652 -1.3039 Td
(post-infection)Tj
5.8223 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1A)Tj
2.1996 0 Td
(Fig)Tj
0 g
(\).)Tj
2.041 0 Td
(Mtb)Tj
1.9219 0 Td
(was)Tj
1.6951 0 Td
(detectable)Tj
4.2292 0 Td
(in)Tj
1.0318 0 Td
(perigonadal)Tj
4.9663 0 Td
(fat)Tj
1.2359 0 Td
(of)Tj
1.0148 0 Td
(17%)Tj
1.9332 0 Td
(to)Tj
1.0205 0 Td
(83%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(mice)Tj
2.1486 0 Td
(at)Tj
0.9525 0 Td
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