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The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly

MPG-Autoren
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Schlaitz,  Anne-Lore
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Srayko,  Martin
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Quintin,  Sophie
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Wielsch,  Natalie
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Zinke,  Andrea
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Muller-Reichert,  Thomas
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Shevchenko,  Andrej
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Oegema,  Karen
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Hyman,  Anthony A.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Zitation

Schlaitz, A.-L., Srayko, M., Dammermann, A., Quintin, S., Wielsch, N., MacLeod, I., et al. (2007). The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell, 128(1), 115-127.


Zitierlink: https://hdl.handle.net/21.11116/0000-0001-0FAC-E
Zusammenfassung
Microtubule behavior changes during the cell cycle and during spindle assembly. However, it remains unclear how these changes are regulated and coordinated. We describe a complex that targets the Protein Phosphatase 2A holoenzyme (PP2A) to centrosomes in C. elegans embryos. This complex includes Regulator of Spindle Assembly 1 (RSA-1), a targeting subunit for PP2A, and RSA-2, a protein that binds and recruits RSA-1 to centrosomes. In contrast to the multiple functions of the PP2A catalytic subunit, RSA-1 and RSA-2 are specifically required for microtubule outgrowth from centrosomes and for spindle assembly. The centrosomally localized RSA-PP2A complex mediates these functions in part by regulating two critical mitotic effectors: the microtubule destabilizer KLP-7 and the C. elegans regulator of spindle assembly TPXL-1. By regulating a subset of PP2A functions at the centrosome, the RSA complex could therefore provide a means of coordinating microtubule outgrowth from centrosomes and kinetochore microtubule stability during mitotic spindle assembly.