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Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea
Susann Michanski, Katharina Smaluch, Anna Maria Steyer, Rituparna Chakrabarti, Cristian Setz, David Oestreicher, Christian Fischer, Wiebke Möbius, Tobias Moser, Christian Vogl, and Carolin Wichmann
Susann Michanski
aMolecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany;bCollaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany;
Katharina Smaluch
bCollaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany;cInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;dPresynaptogenesis and Intracellular Transport in Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;
Anna Maria Steyer
eElectron Microscopy Core Unit, Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany;fCenter Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37075 Göttingen, Germany;
Rituparna Chakrabarti
aMolecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany;bCollaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany;
Cristian Setz
bCollaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany;cInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;dPresynaptogenesis and Intracellular Transport in Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;gDepartment of Otolaryngology, Head and Neck Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany;hAuditory Neuroscience Group, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany;
David Oestreicher
cInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;dPresynaptogenesis and Intracellular Transport in Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;gDepartment of Otolaryngology, Head and Neck Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany;
Christian Fischer
iJohann Friedrich Blumenbach Institute for Zoology and Anthropology, Department of Animal Evolution and Biodiversity, Georg August University of Göttingen, 37073 Göttingen, Germany;
Wiebke Möbius
eElectron Microscopy Core Unit, Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany;fCenter Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37075 Göttingen, Germany;
Tobias Moser
bCollaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany;cInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;fCenter Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37075 Göttingen, Germany;hAuditory Neuroscience Group, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany;jSynaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
Christian Vogl
bCollaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany;cInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;dPresynaptogenesis and Intracellular Transport in Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany;hAuditory Neuroscience Group, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany;
Carolin Wichmann
aMolecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany;bCollaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany;hAuditory Neuroscience Group, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany;
Supporting Information
- Download Appendix (PDF)
- Download Movie_S01 (WMV) - Movie scanning through a representative FIB-SEM z-stack of a P15 IHC, showing 3D reconstruction of the basolateral IHC contour, part of the nucleus, mitochondria, innervating nerve fibers, synaptic ribbons and their corresponding SVs. The movie starts at the nuclear region and extends towards the base of the cochlear IHC. Higher resolution of this video can be found using this link: http://www.innerearlab.uni-goettingen.de/materials.html
- Download Movie_S02 (WMV) - Movie scanning through a FIB-SEM z-stack of the supranuclear part of two neighboring P9 IHCs, shown in Fig. S7K. No ribbon precursors or ribbons could be observed in this dataset. Scale bar: 5 μm. Higher resolution of this video can be found using this link: http://www.innerearlab.uni-goettingen.de/materials.html