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Journal Article

Neuroimaging technological advancements for targeting in functional neurosurgery

MPS-Authors
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Steele,  Christopher
Department of Psychology, Concordia University, Montréal, QC, Canada;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource

https://discovery.ucl.ac.uk/id/eprint/10092379/
(Preprint)

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Citation

Boutet, A., Gramer, R., Steele, C., Elias, G. J. B., Germann, J., Maciel, R., et al. (2019). Neuroimaging technological advancements for targeting in functional neurosurgery. Current Neurology and Neuroscience Reports, 19: 42. doi:10.1007/s11910-019-0961-8.


Cite as: https://hdl.handle.net/21.11116/0000-0003-C7E6-9
Abstract
Purpose of Review

Ablations and particularly deep brain stimulation (DBS) of a variety of CNS targets are established therapeutic tools for movement disorders. Accurate targeting of the intended structure is crucial for optimal clinical outcomes. However, most targets used in functional neurosurgery are sub-optimally visualized on routine MRI. This article reviews recent neuroimaging advancements for targeting in movement disorders.
Recent Findings

Dedicated MRI sequences can often visualize to some degree anatomical structures commonly targeted during DBS surgery, including at 1.5-T field strengths. Due to recent technological advancements, MR images using ultra-high magnetic field strengths and new acquisition parameters allow for markedly improved visualization of common movement disorder targets. In addition, novel neuroimaging techniques have enabled group-level analysis of DBS patients and delineation of areas associated with clinical benefits. These areas might diverge from the conventionally targeted nuclei and may instead correspond to white matter tracts or hubs of functional networks.
Summary

Neuroimaging advancements have enabled improved direct visualization-based targeting as well as optimization and adjustment of conventionally targeted structures.