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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site
Edmond R. Watson, Christy R. R. Grace, Wei Zhang, Darcie J. Miller, Iain F. Davidson, J. Rajan Prabu, Shanshan Yu, Derek L. Bolhuis, Elizaveta T. Kulko, Ronnald Vollrath, David Haselbach, Holger Stark, Jan-Michael Peters, Nicholas G. Brown, Sachdev S. Sidhu, and Brenda A. Schulman
Edmond R. Watson
aDepartment of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105;bDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Christy R. R. Grace
aDepartment of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105;
Wei Zhang
cDonnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada M5S3E1;dDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S3E1;
Darcie J. Miller
aDepartment of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105;
Iain F. Davidson
eResearch Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria;
J. Rajan Prabu
bDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Shanshan Yu
aDepartment of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105;
Derek L. Bolhuis
fDepartment of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599;
Elizaveta T. Kulko
fDepartment of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599;
Ronnald Vollrath
bDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
David Haselbach
eResearch Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria;gMax Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany;
Holger Stark
gMax Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany;
Jan-Michael Peters
eResearch Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria;hMedical University of Vienna, 1090 Vienna, Austria
Nicholas G. Brown
aDepartment of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105;fDepartment of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599;
Sachdev S. Sidhu
cDonnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada M5S3E1;
Brenda A. Schulman
aDepartment of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105;bDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;