Genetic diversity of HLA system in two populations from Oaxaca, Mexico: Oaxaca 
city and rural Oaxaca

Hernández-Hernández, Ofelia; Hernández-Zaragoza, Diana Iraíz; Barquera, Rodrigo; Warinner, Christina G.; López-Gil, Concepción; Arrieta-Bolaños, Esteban; Clayton, Stephen; Bravo-Acevedo, Alicia; la Cruz, Flor del Rocío Ramos-de; Méndez-Mani, Patricia; de Pavón-Vargas, María los Ángeles; Zúñiga, Joaquín; Yunis, Edmond J.; Bekker-Méndez, Carolina; Granados, Julio

doi:10.1016/j.humimm.2019.07.278

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Genetic diversity of HLA system in two populations from Oaxaca, Mexico: Oaxaca city and rural Oaxaca

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Barquera, Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Warinner, Christina G.
Kostbare Kulturen, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton, Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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引用

Hernández-Hernández, O., Hernández-Zaragoza, D. I., Barquera, R., Warinner, C. G., López-Gil, C., Arrieta-Bolaños, E., Clayton, S., Bravo-Acevedo, A., la Cruz, F.-d.-R.-R.-d., Méndez-Mani, P., de Pavón-Vargas, M. l. Á., Zúñiga, J., Yunis, E. J., Bekker-Méndez, C., & Granados, J. (2020). Genetic diversity of HLA system in two populations from Oaxaca, Mexico: Oaxaca city and rural Oaxaca. Human Immunology, 81(9), 553-556. doi:10.1016/j.humimm.2019.07.278.

引用: https://hdl.handle.net/21.11116/0000-0004-5ACB-3

要旨

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 636 Mexicans from the state of Oaxaca living in the city of Oaxaca (N = 151) and rural communities (N = 485), to obtain information regarding allelic and haplotypic frequencies. We found that the 13 most frequent haplotypes in Oaxaca are all of putative Native American origin. Admixture estimates revealed that the main genetic components in the state of Oaxaca are Native American (73.12 ± 2.77 by ML; 61.52 of Native American haplotypes) and European (17.36 ± 2.07 by ML; 20.69 of European haplotypes), and a relatively high African genetic component (9.52 ± 0.88 by ML; 8.94 of African haplotypes).