Systematic hydrogen-bond manipulations to establish polysaccharide 
structure–property correlations

Yu, Yang; Tyrikos-Ergas, Theodore; Zhu, Yuntao; Fittolani, Giulio; Bordoni, Vittorio; Singhal, Ankush; Fair, Richard J.; Grafmüller, Andrea; Seeberger, Peter H.; Delbianco, Martina

doi:10.1002/anie.201906577

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学術論文

Systematic hydrogen-bond manipulations to establish polysaccharide structure–property correlations

MPS-Authors

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Yu, Yang
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons227007

Tyrikos-Ergas, Theodore
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons238081

Zhu, Yuntao
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons238414

Fittolani, Giulio
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons239818

Bordoni, Vittorio
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons240065

Singhal, Ankush
Andrea Grafmüller, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons146371

Fair, Richard J.
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121351

Grafmüller, Andrea
Andrea Grafmüller, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121849

Seeberger, Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons187996

Delbianco, Martina
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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引用

Yu, Y., Tyrikos-Ergas, T., Zhu, Y., Fittolani, G., Bordoni, V., Singhal, A., Fair, R. J., Grafmüller, A., Seeberger, P. H., & Delbianco, M. (2019). Systematic hydrogen-bond manipulations to establish polysaccharide structure–property correlations. Angewandte Chemie International Edition, 58(37), 13127-13132. doi:10.1002/anie.201906577.

引用: https://hdl.handle.net/21.11116/0000-0004-627D-2

要旨

A dense hydrogen bond network is responsible for the mechanical and structural properties of polysaccharides. Random derivatization alters thematerial bulk properties by disrupting the hydrogen bonds, but obstructs detailed structure-function correlations. We prepare well-defined unnatural oligosaccharidesincludingmethylated, deoxygenated, deoxyfluorinated, as well as carboxymethylated cellulose and chitin analogueswith full control over degree and patternof substitution.Molecular dynamics simulationsand crystallographic analysis showhow distinct H-bond modifications drastically affect thesolubility, aggregation behaviour, and crystallinityof carbohydratematerials. This systematic approachto establishingdetailed structure-propertycorrelations will guide the synthesis of novel, tailor-made carbohydrate materials.