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Simultaneous precise editing of multiple genes in human cells

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Riesenberg,  Stephan       
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Chintalapati,  Manjusha       
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Macak,  Dominik
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Kanis,  Philipp       
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Maricic,  Tomislav       
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Pääbo,  Svante       
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
Neandertals and more, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Citation

Riesenberg, S., Chintalapati, M., Macak, D., Kanis, P., Maricic, T., & Pääbo, S. (2019). Simultaneous precise editing of multiple genes in human cells. Nucleic Acids Research, 47(19): e116. doi:10.1093/nar/gkz669.


Cite as: https://hdl.handle.net/21.11116/0000-0004-6AE5-3
Abstract
Abstract. When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results in