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citation_title: Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
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og:site_name: PubMed Central (PMC)
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citation_journal_title: eLife
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ncbi_pcid: /articles/PMC6855807/
citation_date: 2019
title: Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
ncbi_phid: CE8CA6DBDE7A2FA10000000000A9005C.m_8
og:description: Intracellular trafficking depends on the function of Rab GTPases, whose activation is regulated by guanine exchange factors (GEFs). The Rab5 GEF, Rabex5, was previously proposed to be auto-inhibited by its C-terminus. Here, we studied full-length Rabex5 ...
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dc:title: Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
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DC.Publisher: eLife Sciences Publications, Ltd
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DC.Contributor: Janelle Lauer
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citation_pmid: 31718772
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DC.Identifier: 10.7554/eLife.46302
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og:title: Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
DC.Title: Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
citation_abstract_html_url: /pmc/articles/PMC6855807/?report=abstract
citation_authors: Janelle Lauer, Sandra Segeletz, Alice Cezanne, Giambattista Guaitoli, Francesco Raimondi, Marc Gentzel, Vikram Alva, Michael Habeck, Yannis Kalaidzidis, Marius Ueffing, Andrei N Lupas, Christian Johannes Gloeckner, Marino Zerial
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citation_doi: 10.7554/eLife.46302
DC.Language: en
DC.Date: 2019
ncbi_domain: elife
citation_volume: 8
og:url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855807/
Content-Language: en