date: 2019-12-11T09:45:45Z
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pdf:docinfo:title: Automated glycan assembly of arabinomannan oligosaccharides from Mycobacterium tuberculosis
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dc:description: Arabinomannan (AM) polysaccharides are clinical biomarkers for Mycobacterium tuberculosis (MTB) infections due to their roles in the interaction with host cells and interference with macrophage activation. Collections of defined AM oligosaccharides can help to improve the understanding of these polysaccharides and the development of novel therapeutical and diagnostic agents. Automated glycan assembly (AGA) was employed to prepare the core structure of AM from MTB, containing ?-(1,6)-Man, ?-(1,5)-Ara, and ?-(1,2)-Man linkages. The introduction of a capping step after each glycosylation and further optimized reaction conditions allowed for the synthesis of a series of oligosaccharides, ranging from hexa- to branched dodecasaccharides.

Keywords: arabinomannan automated glycan assembly capping
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subject: arabinomannan automated glycan assembly capping
dc:creator: Alonso Pardo-Vargas
description: Arabinomannan (AM) polysaccharides are clinical biomarkers for Mycobacterium tuberculosis (MTB) infections due to their roles in the interaction with host cells and interference with macrophage activation. Collections of defined AM oligosaccharides can help to improve the understanding of these polysaccharides and the development of novel therapeutical and diagnostic agents. Automated glycan assembly (AGA) was employed to prepare the core structure of AM from MTB, containing ?-(1,6)-Man, ?-(1,5)-Ara, and ?-(1,2)-Man linkages. The introduction of a capping step after each glycosylation and further optimized reaction conditions allowed for the synthesis of a series of oligosaccharides, ranging from hexa- to branched dodecasaccharides.

dcterms:created: 2019-12-06T13:03:16Z
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title: Automated glycan assembly of arabinomannan oligosaccharides from Mycobacterium tuberculosis
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pdf:docinfo:keywords: arabinomannan automated glycan assembly capping
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dc:title: Automated glycan assembly of arabinomannan oligosaccharides from Mycobacterium tuberculosis
modified: 2019-12-11T09:45:45Z
Content-Type: application/pdf
pdf:docinfo:creator: Alonso Pardo-Vargas, Priya Bharate, Martina Delbianco, Peter H. Seeberger
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creator: Alonso Pardo-Vargas
meta:author: Alonso Pardo-Vargas
dc:subject: arabinomannan automated glycan assembly capping
meta:creation-date: 2019-12-06T13:03:16Z
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Author: Alonso Pardo-Vargas
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pdf:docinfo:producer: Beilstein Publishing System 5.1.2 and iText 2.1.7 (by lowagie.com)
pdf:docinfo:created: 2019-12-06T13:03:16Z