%PDF-1.3
%
1 0 obj
<<
/Author (Pavlos Stephanos Bekiaris)
/CreationDate (D:20200113222448+08'00')
/Creator (Arbortext Advanced Print Publisher 9.1.440/W Unicode)
/Keywords (Flux balance analysis,Escherichia coli,Metabolic modeling,Enzyme constraints,Protein allocation,Minimal cut sets,Proteomics)
/ModDate (D:20200114175915+01'00')
/Producer (Acrobat Distiller 10.0.0 \(Windows\); modified using iText 5.3.5 2000-2012 1T3XT BVBA \(SPRINGER SBM; licensed version\))
/Subject (BMC Bioinformatics, 2019, doi:10.1186/s12859-019-3329-9)
/Title (Automatic construction of metabolic models with enzyme constraints)
>>
endobj
2 0 obj
<<
/Metadata 3 0 R
/Names 4 0 R
/Outlines 5 0 R
/OutputIntents 6 0 R
/Pages 7 0 R
/Type /Catalog
>>
endobj
3 0 obj
<<
/Length 19811
/Subtype /XML
/Type /Metadata
>>
stream
Flux balance analysis,Escherichia coli,Metabolic modeling,Enzyme constraints,Protein allocation,Minimal cut sets,Proteomics
Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
application/pdf
10.1186/s12859-019-3329-9
BMC Bioinformatics
BMC Bioinformatics, 2019, doi:10.1186/s12859-019-3329-9
Flux balance analysis
Escherichia coli
Metabolic modeling
Enzyme constraints
Protein allocation
Minimal cut sets
Proteomics
Automatic construction of metabolic models with enzyme constraints
Pavlos Stephanos Bekiaris
Steffen Klamt
2020-01-14T17:59:15+01:00
2020-01-14T17:59:15+01:00
2020-01-13T22:24:48+08:00
Arbortext Advanced Print Publisher 9.1.440/W Unicode
uuid:3e60b6e3-4e2c-488a-ad28-24d7334ecfaa
uuid:4fd7276d-cd7a-440f-965c-4399892f1233
default
1
converted
uuid:3e60b6e3-4e2c-488a-ad28-24d7334ecfaa
converted to PDF/A-2b
pdfToolbox
2020-01-14T01:21:48+08:00
2
B
Steffen Klamt
http://orcid.org/0000-0003-2563-7561
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
Bag AuthorInformation
external
Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
editorInfo
Bag EditorInformation
external
Editor information: contains the name of each editor and his/her ORCID identifier.
seriesEditorInfo
Bag SeriesEditorInformation
external
Series editor information: contains the name of each series editor and his/her ORCID identifier.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
EditorInformation
http://springernature.com/ns/xmpExtensions/2.0/editorInfo/
editor
Specifies the types of editor information: name and ORCID of an editor.
name
Text
Gives the name of an editor.
orcid
URI
Gives the ORCID of an editor.
SeriesEditorInformation
http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/
seriesEditor
Specifies the types of series editor information: name and ORCID of a series editor.
name
Text
Gives the name of a series editor.
orcid
URI
Gives the ORCID of a series editor.
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/pdfx/1.3/
pdfx
PDF/X ID Schema
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
endstream
endobj
4 0 obj
<<
/Dests 8 0 R
>>
endobj
5 0 obj
<<
/Count 28
/First 9 0 R
/Last 10 0 R
/Type /Outlines
>>
endobj
6 0 obj
[11 0 R 12 0 R]
endobj
7 0 obj
<<
/Count 13
/Kids [13 0 R 14 0 R]
/Type /Pages
/ITXT (5.1.0)
>>
endobj
8 0 obj
<<
/Kids [15 0 R 16 0 R]
>>
endobj
9 0 obj
<<
/C [0 0 0]
/Count 3
/Dest ( s e c t i o n A b s 1)
/F 0
/First 17 0 R
/Last 18 0 R
/Next 19 0 R
/Parent 5 0 R
/Title ( A b s t r a c t)
>>
endobj
10 0 obj
<<
/C [0 0 0]
/Count 0
/Dest ( A r t N o t e 2)
/F 0
/Parent 5 0 R
/Prev 20 0 R
/Title ( P u b l i s h e r s N o t e)
>>
endobj
11 0 obj
<<
/DestOutputProfile 21 0 R
/Info (sRGB IEC61966-2.1)
/OutputCondition (sRGB)
/OutputConditionIdentifier (Custom)
/RegistryName ()
/S /GTS_PDFA1
/Type /OutputIntent
>>
endobj
12 0 obj
<<
/DestOutputProfile 21 0 R
/Info (sRGB IEC61966-2.1)
/OutputCondition (sRGB)
/OutputConditionIdentifier (Custom)
/RegistryName ()
/S /ISO_PDFE1
/Type /OutputIntent
>>
endobj
13 0 obj
<<
/Count 10
/Kids [22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R]
/Parent 7 0 R
/Type /Pages
>>
endobj
14 0 obj
<<
/Count 3
/Kids [32 0 R 33 0 R 34 0 R]
/Parent 7 0 R
/Type /Pages
>>
endobj
15 0 obj
<<
/Limits [( A r t N o t e 2) ( l i n k _ F i g 2)]
/Names [( A r t N o t e 2) 35 0 R ( l i n k _) 36 0 R ( l i n k _ A S e c 1) 37 0 R ( l i n k _ A S e c 2) 38 0 R ( l i n k _ A S e c 3) 39 0 R ( l i n k _ A b s 1) 40 0 R ( l i n k _ B i b 1) 41 0 R ( l i n k _ C R 1) 42 0 R
( l i n k _ C R 1 0) 43 0 R ( l i n k _ C R 1 1) 44 0 R ( l i n k _ C R 1 2) 45 0 R ( l i n k _ C R 1 3) 46 0 R ( l i n k _ C R 1 4) 47 0 R ( l i n k _ C R 1 5) 48 0 R ( l i n k _ C R 1 6) 49 0 R ( l i n k _ C R 1 7) 50 0 R
( l i n k _ C R 1 8) 51 0 R ( l i n k _ C R 1 9) 52 0 R ( l i n k _ C R 2) 53 0 R ( l i n k _ C R 2 0) 54 0 R ( l i n k _ C R 2 1) 55 0 R ( l i n k _ C R 2 2) 56 0 R ( l i n k _ C R 2 3) 57 0 R ( l i n k _ C R 2 4) 58 0 R
( l i n k _ C R 2 5) 59 0 R ( l i n k _ C R 2 6) 60 0 R ( l i n k _ C R 2 7) 61 0 R ( l i n k _ C R 2 8) 62 0 R ( l i n k _ C R 2 9) 63 0 R ( l i n k _ C R 3) 64 0 R ( l i n k _ C R 3 0) 65 0 R ( l i n k _ C R 3 1) 66 0 R
( l i n k _ C R 3 2) 67 0 R ( l i n k _ C R 3 3) 68 0 R ( l i n k _ C R 3 4) 69 0 R ( l i n k _ C R 3 5) 70 0 R ( l i n k _ C R 3 6) 71 0 R ( l i n k _ C R 3 7) 72 0 R ( l i n k _ C R 3 8) 73 0 R ( l i n k _ C R 4) 74 0 R
( l i n k _ C R 5) 75 0 R ( l i n k _ C R 6) 76 0 R ( l i n k _ C R 7) 77 0 R ( l i n k _ C R 8) 78 0 R ( l i n k _ C R 9) 79 0 R ( l i n k _ E q u 1) 80 0 R ( l i n k _ E q u 1 0) 81 0 R ( l i n k _ E q u 1 1) 82 0 R
( l i n k _ E q u 1 2) 83 0 R ( l i n k _ E q u 1 3) 84 0 R ( l i n k _ E q u 1 4) 85 0 R ( l i n k _ E q u 2) 86 0 R ( l i n k _ E q u 3) 87 0 R ( l i n k _ E q u 4) 88 0 R ( l i n k _ E q u 5) 89 0 R ( l i n k _ E q u 6) 90 0 R
( l i n k _ E q u 7) 91 0 R ( l i n k _ E q u 8) 92 0 R ( l i n k _ E q u 9) 93 0 R ( l i n k _ F P a r 1) 94 0 R ( l i n k _ F P a r 2) 95 0 R ( l i n k _ F P a r 3) 96 0 R ( l i n k _ F i g 1) 97 0 R ( l i n k _ F i g 2) 98 0 R]
>>
endobj
16 0 obj
<<
/Limits [( l i n k _ F i g 3) ( s e c t i o n a b r 1)]
/Names [( l i n k _ F i g 3) 99 0 R ( l i n k _ F i g 4) 100 0 R ( l i n k _ F i g 5) 101 0 R ( l i n k _ M O E S M 1) 102 0 R ( l i n k _ M O E S M 2) 103 0 R ( l i n k _ M O E S M 3) 104 0 R ( l i n k _ S e c 1) 105 0 R ( l i n k _ S e c 1 0) 106 0 R
( l i n k _ S e c 1 1) 107 0 R ( l i n k _ S e c 1 2) 108 0 R ( l i n k _ S e c 1 3) 109 0 R ( l i n k _ S e c 1 4) 110 0 R ( l i n k _ S e c 2) 111 0 R ( l i n k _ S e c 3) 112 0 R ( l i n k _ S e c 4) 113 0 R ( l i n k _ S e c 5) 114 0 R
( l i n k _ S e c 6) 115 0 R ( l i n k _ S e c 7) 116 0 R ( l i n k _ S e c 8) 117 0 R ( l i n k _ S e c 9) 118 0 R ( l i n k _ T a b 1) 119 0 R ( l i n k _ T a b 2) 120 0 R ( l i n k _ a b r 1) 121 0 R ( s e c t i o n 1) 122 0 R
( s e c t i o n 2) 123 0 R ( s e c t i o n 3) 124 0 R ( s e c t i o n 4) 125 0 R ( s e c t i o n A S e c 1) 126 0 R ( s e c t i o n A S e c 2) 127 0 R ( s e c t i o n A S e c 3) 128 0 R ( s e c t i o n A b s 1) 129 0 R ( s e c t i o n B i b 1) 130 0 R
( s e c t i o n F P a r 1) 131 0 R ( s e c t i o n F P a r 2) 132 0 R ( s e c t i o n F P a r 3) 133 0 R ( s e c t i o n S e c 1) 134 0 R ( s e c t i o n S e c 1 0) 135 0 R ( s e c t i o n S e c 1 1) 136 0 R ( s e c t i o n S e c 1 2) 137 0 R ( s e c t i o n S e c 1 3) 138 0 R
( s e c t i o n S e c 1 4) 139 0 R ( s e c t i o n S e c 2) 140 0 R ( s e c t i o n S e c 3) 141 0 R ( s e c t i o n S e c 4) 142 0 R ( s e c t i o n S e c 5) 143 0 R ( s e c t i o n S e c 6) 144 0 R ( s e c t i o n S e c 7) 145 0 R ( s e c t i o n S e c 8) 146 0 R
( s e c t i o n S e c 9) 147 0 R ( s e c t i o n a b r 1) 148 0 R]
>>
endobj
17 0 obj
<<
/C [0 0 0]
/Count 0
/Dest ( s e c t i o n A S e c 1)
/F 0
/Next 149 0 R
/Parent 9 0 R
/Title ( B a c k g r o u n d)
>>
endobj
18 0 obj
<<
/C [0 0 0]
/Count 0
/Dest ( s e c t i o n A S e c 3)
/F 0
/Parent 9 0 R
/Prev 149 0 R
/Title ( C o n c l u s i o n s)
>>
endobj
19 0 obj
<<
/C [0 0 0]
/Count 0
/Dest ( s e c t i o n S e c 1)
/F 0
/Next 150 0 R
/Parent 5 0 R
/Prev 9 0 R
/Title ( B a c k g r o u n d)
>>
endobj
20 0 obj
<<
/C [0 0 0]
/Count 0
/Dest ( s e c t i o n B i b 1)
/F 0
/Next 10 0 R
/Parent 5 0 R
/Prev 151 0 R
/Title ( R e f e r e n c e s)
>>
endobj
21 0 obj
<<
/Filter [/FlateDecode]
/Length 2574
/N 3
/Range [0 1 0 1 0 1]
>>
stream
HyTSwoɞc
[5laQIBHADED2mtFOE.c}088GNg9w߽ '0 ֠Jb
2y.-;!KZ ^i"L0-
@8(r;q7Ly&Qq4j|9
V)gB0iW8#8wթ8_٥ʨQQj@&A)/g>'K t;\
ӥ$պFZUn(4T%)뫔0C&Zi8bxEB;Pӓ̹Aom?W=
x- [ 0}y)7ta>jT7@tܛ`q2ʀ&6ZLĄ?_yxg)˔zçLU*uSkSeO4?c. R
߁-25 S>ӣVd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L`< "AYA+Cb(R, *T2B-
ꇆnQt}MA0alSx k&^>0|>_',G!"F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VĭKĻYdE"EI2EBGt4MzNr!YK ?%_(0J:EAiQ(()ӔWT6U@P+!~mDeԴ!hӦh/']B/ҏӿ?a0nhF!X8܌kc&5S6lIa2cKMA!E#ƒdV(kel
}}Cq9
N')].uJr
wG xR^[oƜchg`>b$*~ :Eb~,m,-ݖ,Y¬*6X[ݱF=3뭷Y~dó tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:˜O:ϸ8uJqnv=MmR 4
n3ܣkGݯz=[==<=GTB(/S,]6*-W:#7*e^YDY}UjAyT`#D="b{ų+ʯ:!kJ4Gmt}uC%K7YVfFY.=b?SƕƩȺy
چk5%4m7lqlioZlG+Zzmzy]?uuw|"űNwW&e֥ﺱ*|j5kyݭǯg^ykEklD_p߶7Dmo꿻1ml{Mś
nLl<9O [$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD- u`ֲK³8%yhYѹJº;.!
zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs
2F[p(@Xr4Pm8Ww)Km
endstream
endobj
22 0 obj
<<
/Annots [152 0 R 153 0 R 154 0 R 155 0 R 156 0 R]
/Contents 157 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS1 159 0 R
/GS2 160 0 R
/GS8 161 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F4 165 0 R
/F5 166 0 R
/F6 167 0 R
/F8 168 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/Properties <<
/MC1 169 0 R
/MC2 170 0 R
/MC3 171 0 R
/MC4 172 0 R
/MC5 173 0 R
/MC6 174 0 R
/MC7 175 0 R
/MC8 176 0 R
>>
/Shading <<
/Sh1 177 0 R
>>
/XObject <<
/Im1 178 0 R
/Im2 179 0 R
/Im3 180 0 R
>>
>>
/Rotate 0
/Thumb 181 0 R
/Type /Page
>>
endobj
23 0 obj
<<
/Annots [182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R
198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R]
/Contents 210 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 168 0 R
/F6 167 0 R
/F8 211 0 R
/F9 212 0 R
/F10 213 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Thumb 214 0 R
/Type /Page
>>
endobj
24 0 obj
<<
/Annots [215 0 R 216 0 R 217 0 R 218 0 R]
/Contents 219 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
/GS3 220 0 R
/GS4 161 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F4 165 0 R
/F5 166 0 R
/F6 167 0 R
/F8 211 0 R
/F9 212 0 R
/F10 213 0 R
/F11 221 0 R
/F12 222 0 R
/F13 223 0 R
/F14 224 0 R
/F15 225 0 R
/F16 226 0 R
/F17 227 0 R
/F18 228 0 R
/F19 168 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageB /ImageI]
/XObject <<
/Im4 229 0 R
>>
>>
/Rotate 0
/Thumb 230 0 R
/Type /Page
>>
endobj
25 0 obj
<<
/Annots [231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R 238 0 R 239 0 R 240 0 R 241 0 R]
/Contents 242 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
>>
/Font <<
/F1 168 0 R
/F2 163 0 R
/F6 167 0 R
/F8 211 0 R
/F9 212 0 R
/F10 213 0 R
/F12 222 0 R
/F14 224 0 R
/F15 225 0 R
/F16 226 0 R
/F17 227 0 R
/F18 228 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Thumb 243 0 R
/Type /Page
>>
endobj
26 0 obj
<<
/Annots [244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R 250 0 R 251 0 R]
/Contents 252 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
/GS4 161 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F4 165 0 R
/F6 167 0 R
/F8 211 0 R
/F9 212 0 R
/F10 213 0 R
/F11 168 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageB /ImageI]
/XObject <<
/Im5 253 0 R
>>
>>
/Rotate 0
/Thumb 254 0 R
/Type /Page
>>
endobj
27 0 obj
<<
/Annots [255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R 270 0 R
271 0 R 272 0 R 273 0 R]
/Contents 274 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F4 165 0 R
/F5 166 0 R
/F6 167 0 R
/F8 211 0 R
/F9 212 0 R
/F10 213 0 R
/F12 222 0 R
/F15 168 0 R
/F16 226 0 R
/F17 227 0 R
/F19 275 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Thumb 276 0 R
/Type /Page
>>
endobj
28 0 obj
<<
/Annots [277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R 284 0 R 285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R 291 0 R 292 0 R
293 0 R 294 0 R 295 0 R 296 0 R]
/Contents 297 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
>>
/Font <<
/F1 168 0 R
/F2 163 0 R
/F4 165 0 R
/F6 167 0 R
/F8 211 0 R
/F9 212 0 R
/F10 213 0 R
/F12 222 0 R
/F14 224 0 R
/F15 225 0 R
/F16 226 0 R
/F17 227 0 R
/F18 228 0 R
/F19 275 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Thumb 298 0 R
/Type /Page
>>
endobj
29 0 obj
<<
/Annots [299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R 307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R]
/Contents 313 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
/GS4 161 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F4 165 0 R
/F5 166 0 R
/F6 167 0 R
/F8 211 0 R
/F10 213 0 R
/F11 168 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Im6 314 0 R
>>
>>
/Rotate 0
/Thumb 315 0 R
/Type /Page
>>
endobj
30 0 obj
<<
/Annots [316 0 R 317 0 R 318 0 R 319 0 R 320 0 R 321 0 R 322 0 R]
/Contents 323 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
/GS3 220 0 R
/GS4 161 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F4 165 0 R
/F5 166 0 R
/F6 167 0 R
/F8 211 0 R
/F9 212 0 R
/F10 213 0 R
/F12 168 0 R
/F15 225 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageB /ImageI]
/XObject <<
/Im7 324 0 R
>>
>>
/Rotate 0
/Thumb 325 0 R
/Type /Page
>>
endobj
31 0 obj
<<
/Annots [326 0 R 327 0 R]
/Contents 328 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 13 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
/GS3 220 0 R
/GS4 161 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F5 166 0 R
/F6 167 0 R
/F8 211 0 R
/F10 213 0 R
/F11 168 0 R
/F20 329 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageB /ImageI]
/XObject <<
/Im8 330 0 R
>>
>>
/Rotate 0
/Thumb 331 0 R
/Type /Page
>>
endobj
32 0 obj
<<
/Annots [332 0 R 333 0 R 334 0 R 335 0 R 336 0 R 337 0 R 338 0 R 339 0 R 340 0 R]
/Contents 341 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 14 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 168 0 R
/F6 167 0 R
/F8 211 0 R
/F10 213 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Thumb 342 0 R
/Type /Page
>>
endobj
33 0 obj
<<
/Annots [343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R]
/Contents 350 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 14 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F4 165 0 R
/F5 166 0 R
/F6 167 0 R
/F8 211 0 R
/F9 212 0 R
/F10 213 0 R
/F12 168 0 R
/F21 351 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Rotate 0
/Thumb 352 0 R
/Type /Page
>>
endobj
34 0 obj
<<
/Annots [353 0 R 354 0 R 355 0 R 356 0 R 357 0 R 358 0 R 359 0 R]
/Contents 360 0 R
/CropBox [0 0 595.276 790.866]
/MediaBox [0 0 595.276 790.866]
/Parent 14 0 R
/Resources <<
/ColorSpace <<
/Cs6 158 0 R
>>
/ExtGState <<
/GS2 159 0 R
>>
/Font <<
/F1 162 0 R
/F2 163 0 R
/F3 164 0 R
/F4 165 0 R
/F5 166 0 R
/F6 167 0 R
/F11 168 0 R
/F20 329 0 R
/F22 361 0 R
/F23 362 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/Properties <<
/MC9 363 0 R
>>
/XObject <<
/Im9 364 0 R
>>
>>
/Rotate 0
/Thumb 365 0 R
/Type /Page
>>
endobj
35 0 obj
<<
/D [34 0 R /FitR 0 207 596 207]
>>
endobj
36 0 obj
<<
/D [33 0 R /FitR 0 105 596 105]
>>
endobj
37 0 obj
<<
/D [22 0 R /FitR 0 557 596 557]
>>
endobj
38 0 obj
<<
/D [22 0 R /FitR 0 470 596 470]
>>
endobj
39 0 obj
<<
/D [22 0 R /FitR 0 287 596 287]
>>
endobj
40 0 obj
<<
/D [22 0 R /FitR 0 577 596 577]
>>
endobj
41 0 obj
<<
/D [34 0 R /FitR 0 516 596 516]
>>
endobj
42 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
43 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
44 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
45 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
46 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
47 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
48 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
49 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
50 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
51 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
52 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
53 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
54 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
55 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
56 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
57 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
58 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
59 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
60 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
61 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
62 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
63 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
64 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
65 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
66 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
67 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
68 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
69 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
70 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
71 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
72 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
73 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
74 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
75 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
76 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
77 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
78 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
79 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
80 0 obj
<<
/D [24 0 R /FitR 0 552 596 552]
>>
endobj
81 0 obj
<<
/D [25 0 R /FitR 0 271 596 271]
>>
endobj
82 0 obj
<<
/D [25 0 R /FitR 0 207 596 207]
>>
endobj
83 0 obj
<<
/D [25 0 R /FitR 0 320 596 320]
>>
endobj
84 0 obj
<<
/D [27 0 R /FitR 0 456 596 456]
>>
endobj
85 0 obj
<<
/D [28 0 R /FitR 0 192 596 192]
>>
endobj
86 0 obj
<<
/D [24 0 R /FitR 0 514 596 514]
>>
endobj
87 0 obj
<<
/D [24 0 R /FitR 0 344 596 344]
>>
endobj
88 0 obj
<<
/D [24 0 R /FitR 0 306 596 306]
>>
endobj
89 0 obj
<<
/D [24 0 R /FitR 0 197 596 197]
>>
endobj
90 0 obj
<<
/D [24 0 R /FitR 0 576 596 576]
>>
endobj
91 0 obj
<<
/D [24 0 R /FitR 0 513 596 513]
>>
endobj
92 0 obj
<<
/D [24 0 R /FitR 0 463 596 463]
>>
endobj
93 0 obj
<<
/D [25 0 R /FitR 0 408 596 408]
>>
endobj
94 0 obj
<<
/D [34 0 R /FitR 0 624 596 624]
>>
endobj
95 0 obj
<<
/D [34 0 R /FitR 0 597 596 597]
>>
endobj
96 0 obj
<<
/D [34 0 R /FitR 0 570 596 570]
>>
endobj
97 0 obj
<<
/D [24 0 R /FitR 0 791 596 0]
>>
endobj
98 0 obj
<<
/D [26 0 R /FitR 0 791 596 0]
>>
endobj
99 0 obj
<<
/D [29 0 R /FitR 0 791 596 0]
>>
endobj
100 0 obj
<<
/D [30 0 R /FitR 0 791 596 0]
>>
endobj
101 0 obj
<<
/D [31 0 R /FitR 0 791 596 0]
>>
endobj
102 0 obj
<<
/D [33 0 R /FitR 0 396 596 396]
>>
endobj
103 0 obj
<<
/D [33 0 R /FitR 0 375 596 375]
>>
endobj
104 0 obj
<<
/D [33 0 R /FitR 0 345 596 345]
>>
endobj
105 0 obj
<<
/D [23 0 R /FitR 0 708 596 708]
>>
endobj
106 0 obj
<<
/D [29 0 R /FitR 0 468 596 468]
>>
endobj
107 0 obj
<<
/D [29 0 R /FitR 0 240 596 240]
>>
endobj
108 0 obj
<<
/D [32 0 R /FitR 0 622 596 622]
>>
endobj
109 0 obj
<<
/D [33 0 R /FitR 0 583 596 583]
>>
endobj
110 0 obj
<<
/D [33 0 R /FitR 0 439 596 439]
>>
endobj
111 0 obj
<<
/D [24 0 R /FitR 0 612 596 612]
>>
endobj
112 0 obj
<<
/D [24 0 R /FitR 0 600 596 600]
>>
endobj
113 0 obj
<<
/D [26 0 R /FitR 0 468 596 468]
>>
endobj
114 0 obj
<<
/D [27 0 R /FitR 0 142 596 142]
>>
endobj
115 0 obj
<<
/D [27 0 R /FitR 0 130 596 130]
>>
endobj
116 0 obj
<<
/D [27 0 R /FitR 0 396 596 396]
>>
endobj
117 0 obj
<<
/D [28 0 R /FitR 0 576 596 576]
>>
endobj
118 0 obj
<<
/D [28 0 R /FitR 0 264 596 264]
>>
endobj
119 0 obj
<<
/D [27 0 R /FitR 0 791 596 0]
>>
endobj
120 0 obj
<<
/D [31 0 R /FitR 0 791 596 0]
>>
endobj
121 0 obj
<<
/D [33 0 R /FitR 0 312 596 312]
>>
endobj
122 0 obj
<<
/D [33 0 R /FitR 0 249 596 249]
>>
endobj
123 0 obj
<<
/D [33 0 R /FitR 0 222 596 222]
>>
endobj
124 0 obj
<<
/D [33 0 R /FitR 0 168 596 168]
>>
endobj
125 0 obj
<<
/D [33 0 R /FitR 0 105 596 105]
>>
endobj
126 0 obj
<<
/D [22 0 R /FitR 0 791 596 791]
>>
endobj
127 0 obj
<<
/D [22 0 R /FitR 0 791 596 791]
>>
endobj
128 0 obj
<<
/D [22 0 R /FitR 0 287 596 287]
>>
endobj
129 0 obj
<<
/D [22 0 R /FitR 0 791 596 791]
>>
endobj
130 0 obj
<<
/D [34 0 R /FitR 0 791 596 791]
>>
endobj
131 0 obj
<<
/D [34 0 R /FitR 0 791 596 791]
>>
endobj
132 0 obj
<<
/D [34 0 R /FitR 0 791 596 791]
>>
endobj
133 0 obj
<<
/D [34 0 R /FitR 0 791 596 791]
>>
endobj
134 0 obj
<<
/D [23 0 R /FitR 0 791 596 791]
>>
endobj
135 0 obj
<<
/D [29 0 R /FitR 0 791 596 791]
>>
endobj
136 0 obj
<<
/D [29 0 R /FitR 0 240 596 240]
>>
endobj
137 0 obj
<<
/D [32 0 R /FitR 0 791 596 791]
>>
endobj
138 0 obj
<<
/D [33 0 R /FitR 0 791 596 791]
>>
endobj
139 0 obj
<<
/D [33 0 R /FitR 0 791 596 791]
>>
endobj
140 0 obj
<<
/D [24 0 R /FitR 0 791 596 791]
>>
endobj
141 0 obj
<<
/D [24 0 R /FitR 0 791 596 791]
>>
endobj
142 0 obj
<<
/D [26 0 R /FitR 0 791 596 791]
>>
endobj
143 0 obj
<<
/D [27 0 R /FitR 0 142 596 142]
>>
endobj
144 0 obj
<<
/D [27 0 R /FitR 0 130 596 130]
>>
endobj
145 0 obj
<<
/D [27 0 R /FitR 0 396 596 396]
>>
endobj
146 0 obj
<<
/D [28 0 R /FitR 0 791 596 791]
>>
endobj
147 0 obj
<<
/D [28 0 R /FitR 0 264 596 264]
>>
endobj
148 0 obj
<<
/D [33 0 R /FitR 0 312 596 312]
>>
endobj
149 0 obj
<<
/C [0 0 0]
/Count 0
/Dest ( s e c t i o n A S e c 2)
/F 0
/Next 18 0 R
/Parent 9 0 R
/Prev 17 0 R
/Title ( R e s u l t s)
>>
endobj
150 0 obj
<<
/C [0 0 0]
/Count 2
/Dest ( s e c t i o n S e c 2)
/F 0
/First 366 0 R
/Last 367 0 R
/Next 368 0 R
/Parent 5 0 R
/Prev 19 0 R
/Title ( M e t h o d s)
>>
endobj
151 0 obj
<<
/C [0 0 0]
/Count 0
/Dest ( s e c t i o n F P a r 3)
/F 0
/Next 20 0 R
/Parent 5 0 R
/Prev 369 0 R
/Title ( C o m p e t i n g i n t e r e s t s)
>>
endobj
152 0 obj
<<
/A <<
/S /URI
/URI (http://crossmark.crossref.org/dialog/?doi=10.1186/s12859-019-3329-9&domain=pdf)
>>
/AP <<
/N 370 0 R
>>
/Border [0 0 0]
/F 4
/Rect [496.686 635.414 538.583 677.31]
/Subtype /Link
/Type /Annot
>>
endobj
153 0 obj
<<
/A <<
/S /URI
/URI (http://orcid.org/0000-0003-2563-7561)
>>
/AP <<
/N 371 0 R
>>
/Border [0 0 0]
/F 4
/Rect [244.233 599.641 253.077 608.428]
/Subtype /Link
/Type /Annot
>>
endobj
154 0 obj
<<
/A <<
/S /URI
/URI (http://creativecommons.org/licenses/by/4.0/)
>>
/AP <<
/N 372 0 R
>>
/Border [0 0 0]
/F 4
/Rect [239.074 65.82 357.052 72.85]
/Subtype /Link
/Type /Annot
>>
endobj
155 0 obj
<<
/A <<
/S /URI
/URI (http://creativecommons.org/publicdomain/zero/1.0/)
>>
/AP <<
/N 373 0 R
>>
/Border [0 0 0]
/F 4
/Rect [182.041 41.839 321.165 48.813]
/Subtype /Link
/Type /Annot
>>
endobj
156 0 obj
<<
/A <<
/S /URI
/URI (mailto:klamt@mpi-magdeburg.mpg.de)
>>
/AP <<
/N 374 0 R
>>
/Border [0 0 0]
/F 4
/Rect [114.576 108.68 210.047 116.164]
/Subtype /Link
/Type /Annot
>>
endobj
157 0 obj
<<
/Filter [/FlateDecode]
/Length 13037
>>
stream
x}ۖDZ{E?^:姑(Y,kyF
@dY4IxZfWY\\}^9\KS1-R/S-^n/~\WwrzqHÅY."wbwyX]H5[nZ.cwR
9J-tB}$Kp%y-"),E)\;ۅڴwlZn#JiVR,ױjq3rcR[ᕹ˩^)ҋb\-Eݥ34|nߏm(sF)'zI;H*]\.MM2Q(h72f-ˢXGE%uLdeP _kukGtԒqLA^Emb^ kK"Js
JG
1Hl2롔t.K1L*mvJv@IO* tD#[niEne3QTu+eW糒8aE=k];?۾,PgN⠜~FaNB Nͣעw0sȱndv5aL7eJl\le5nKh3J{ӓ5LKJHR,ʏ9 6+٫g&RN9Dl+YJ_p9mŵ%Rcb( /5!!q8pa(٬_}i:3"?ȏ/䇬j"~O
^}b/2ɶDE4/AuK/+Ŀ[-U h#h*0FBRm!_$ײ+ju6,X9~Kmj"pFJˀ=<ː
es@29iqI\%nJS{,Rxa-X8.>
AU=.$Iu-Tfݯ&x \}l<@~=Ѵ>hg+ĶSm>WBh՛h[!cM}t۶_h_h-hNϻϽ?Oka\zih^#A,'<'3>pƹGLpG'ym4|!J#|c'ByELF,pt
Y,ysH