Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is 
Linked to Changes in Their Morphology.

Kalebic, Nereo; Gilardi, Carlotta; Stepien, Barbara; Wilsch-Bräuninger, Michaela; Long, Katherine S.; Namba, Takashi; Florio, Marta; Langen, Barbara; Lombardot, Benoit; Shevchenko, Anna; Kilimann, Manfred W; Kawasaki, Hiroshi; Wimberger, Pauline; Huttner, Wieland

doi:10.1016/j.stem.2019.02.017

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Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology.

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Kalebic, Nereo
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

Gilardi, Carlotta
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons232147

Stepien, Barbara
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219790

Wilsch-Bräuninger, Michaela
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219479

Namba, Takashi
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219162

Florio, Marta
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219669

Shevchenko, Anna
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219252

Huttner, Wieland
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Kalebic, N., Gilardi, C., Stepien, B., Wilsch-Bräuninger, M., Long, K. S., Namba, T., et al. (2019). Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology. Cell stem cell, 24(4), 535-550. doi:10.1016/j.stem.2019.02.017.

Cite as: https://hdl.handle.net/21.11116/0000-0006-7DEA-7

Abstract

The evolutionary expansion of the mammalian neocortex (Ncx) is thought to be linked to increased proliferative capacity of basal progenitors (BPs) and their neurogenic capacity. Here, by quantifying BP morphology in the developing Ncx of mouse, ferret, and human, we show that increased BP proliferative capacity is linked to an increase in BP process number. We identify human membrane-bound PALMDELPHIN (PALMD-Caax) as an underlying factor, and we show that it drives BP process growth and proliferation when expressed in developing mouse and ferret Ncx. Conversely, CRISPR/Cas9-mediated disruption of PALMD or its binding partner ADDUCIN-γ in fetal human Ncx reduces BP process numbers and proliferation. We further show that PALMD-induced processes enable BPs to receive pro-proliferative integrin-dependent signals. These findings provide a link between BP morphology and proliferation, suggesting that changes in BP morphology may have contributed to the evolutionary expansion of the Ncx.