date: 2020-07-28T13:18:13Z
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pdf:docinfo:title: Synthesis of Streptococcus pneumoniae serotype 9V oligosaccharide antigens
xmp:CreatorTool: Beilstein Journal of Organic Chemistry
dc:description: Streptococcus pneumoniae (SP) bacteria cause serious invasive diseases. SP bacteria are covered by a capsular polysaccharide (CPS) that is a virulence factor and the basis for SP polysaccharide and glycoconjugate vaccines. The serotype 9V is part of the currently marketed conjugate vaccine and contains an acetate modification. To better understand the importance of glycan modifications in general and acetylation in particular, defined oligosaccharide antigens are needed for serological and immunological studies. Here, we demonstrate a convergent [2 + 3] synthetic strategy to prepare the pentasaccharide repeating unit of 9V with and without an acetate group at the C-6 position of mannosamine.

Keywords: antigen carbohydrate chemistry oligosaccharide Streptococcus pneumoniae vaccines
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subject: antigen carbohydrate chemistry oligosaccharide Streptococcus pneumoniae vaccines
dc:creator: Sharavathi G. Parameswarappa
description: Streptococcus pneumoniae (SP) bacteria cause serious invasive diseases. SP bacteria are covered by a capsular polysaccharide (CPS) that is a virulence factor and the basis for SP polysaccharide and glycoconjugate vaccines. The serotype 9V is part of the currently marketed conjugate vaccine and contains an acetate modification. To better understand the importance of glycan modifications in general and acetylation in particular, defined oligosaccharide antigens are needed for serological and immunological studies. Here, we demonstrate a convergent [2 + 3] synthetic strategy to prepare the pentasaccharide repeating unit of 9V with and without an acetate group at the C-6 position of mannosamine.

dcterms:created: 2020-07-15T08:50:07Z
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dcterms:modified: 2020-07-28T13:18:13Z
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title: Synthesis of Streptococcus pneumoniae serotype 9V oligosaccharide antigens
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Last-Save-Date: 2020-07-28T13:18:13Z
pdf:docinfo:creator_tool: Beilstein Journal of Organic Chemistry
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pdf:docinfo:keywords: antigen carbohydrate chemistry oligosaccharide Streptococcus pneumoniae vaccines
pdf:docinfo:modified: 2020-07-28T13:18:13Z
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dc:title: Synthesis of Streptococcus pneumoniae serotype 9V oligosaccharide antigens
modified: 2020-07-28T13:18:13Z
Content-Type: application/pdf
pdf:docinfo:creator: Sharavathi G. Parameswarappa, Claney L. Pereira, Peter H. Seeberger
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creator: Sharavathi G. Parameswarappa
meta:author: Sharavathi G. Parameswarappa
dc:subject: antigen carbohydrate chemistry oligosaccharide Streptococcus pneumoniae vaccines
meta:creation-date: 2020-07-15T08:50:07Z
created: 2020-07-15T08:50:07Z
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meta:keyword: antigen carbohydrate chemistry oligosaccharide Streptococcus pneumoniae vaccines
Author: Sharavathi G. Parameswarappa
producer: Beilstein Publishing System 5.2 and iText 2.1.7 (by lowagie.com)
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pdf:docinfo:producer: Beilstein Publishing System 5.2 and iText 2.1.7 (by lowagie.com)
pdf:docinfo:created: 2020-07-15T08:50:07Z