date: 2020-05-19T11:25:20Z pdf:PDFVersion: 1.6 pdf:docinfo:title: Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors xmp:CreatorTool: Springer access_permission:can_print_degraded: true subject: Retrovirology, https://doi.org/10.1186/s12977-020-00520-6 pdfa:PDFVersion: A-2b xmpMM:History:Action: converted language: EN dc:format: application/pdf; version=1.6 pdf:docinfo:custom:robots: noindex pdf:docinfo:creator_tool: Springer access_permission:fill_in_form: true xmpMM:History:When: 2020-05-15T17:27:33Z pdf:encrypted: false dc:title: Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors modified: 2020-05-19T11:25:20Z cp:subject: Retrovirology, https://doi.org/10.1186/s12977-020-00520-6 xmpMM:History:SoftwareAgent: pdfToolbox pdf:docinfo:custom:CrossMarkDomains[1]: springer.com robots: noindex pdf:docinfo:subject: Retrovirology, https://doi.org/10.1186/s12977-020-00520-6 xmpMM:History:InstanceID: uuid:a77a3607-496a-4195-b5b7-e6f8bb38cfe9 pdf:docinfo:creator: Tomas Bastys meta:author: Vytautas Gapsys meta:creation-date: 2020-05-15T11:56:50Z pdf:docinfo:custom:CrossmarkMajorVersionDate: 2010-04-23 created: 2020-05-15T11:56:50Z access_permission:extract_for_accessibility: true Creation-Date: 2020-05-15T11:56:50Z pdfaid:part: 2 pdf:docinfo:custom:CrossMarkDomains[2]: springerlink.com pdf:docinfo:custom:doi: 10.1186/s12977-020-00520-6 pdf:docinfo:custom:CrossmarkDomainExclusive: true Author: Vytautas Gapsys producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CrossmarkDomainExclusive: true pdf:docinfo:producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) doi: 10.1186/s12977-020-00520-6 pdf:unmappedUnicodeCharsPerPage: 0 dc:description: Retrovirology, https://doi.org/10.1186/s12977-020-00520-6 Keywords: Alchemical binding free energy change calculation,Distant site mutations,HIV-1 protease inhibitors,Hydrogen bond network perturbation,Resistance-associated mutations access_permission:modify_annotations: true dc:creator: Vytautas Gapsys description: Retrovirology, https://doi.org/10.1186/s12977-020-00520-6 dcterms:created: 2020-05-15T11:56:50Z Last-Modified: 2020-05-19T11:25:20Z dcterms:modified: 2020-05-19T11:25:20Z title: Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors xmpMM:DocumentID: uuid:01ad1d7b-03c4-413b-a83d-6b27cf860379 Last-Save-Date: 2020-05-19T11:25:20Z CrossMarkDomains[1]: springer.com pdf:docinfo:keywords: Alchemical binding free energy change calculation,Distant site mutations,HIV-1 protease inhibitors,Hydrogen bond network perturbation,Resistance-associated mutations pdf:docinfo:modified: 2020-05-19T11:25:20Z meta:save-date: 2020-05-19T11:25:20Z Content-Type: application/pdf X-Parsed-By: org.apache.tika.parser.DefaultParser creator: Vytautas Gapsys pdfaid:conformance: B dc:language: EN dc:subject: Alchemical binding free energy change calculation,Distant site mutations,HIV-1 protease inhibitors,Hydrogen bond network perturbation,Resistance-associated mutations access_permission:assemble_document: true xmpTPg:NPages: 14 pdf:charsPerPage: 4436 access_permission:extract_content: true access_permission:can_print: true CrossMarkDomains[2]: springerlink.com meta:keyword: Alchemical binding free energy change calculation,Distant site mutations,HIV-1 protease inhibitors,Hydrogen bond network perturbation,Resistance-associated mutations access_permission:can_modify: true pdf:docinfo:created: 2020-05-15T11:56:50Z CrossmarkMajorVersionDate: 2010-04-23