date: 2020-09-12T09:04:42Z pdf:PDFVersion: 1.5 pdf:docinfo:title: Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells xmp:CreatorTool: LaTeX with hyperref package access_permission:can_print_degraded: true subject: Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used. dc:format: application/pdf; version=1.5 pdf:docinfo:creator_tool: LaTeX with hyperref package access_permission:fill_in_form: true pdf:encrypted: false dc:title: Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells modified: 2020-09-12T09:04:42Z cp:subject: Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used. pdf:docinfo:subject: Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used. pdf:docinfo:creator: Matthias Krumb, Marie-Luise Frey, Jens Langhanki, Robert Forster, Danuta Kowalczyk, Volker Mailänder, Katharina Landfester and Till Opatz PTEX.Fullbanner: This is pdfTeX, Version 3.14159265-2.6-1.40.18 (TeX Live 2017/W32TeX) kpathsea version 6.2.3 meta:author: Matthias Krumb, Marie-Luise Frey, Jens Langhanki, Robert Forster, Danuta Kowalczyk, Volker Mailänder, Katharina Landfester and Till Opatz trapped: False meta:creation-date: 2020-09-12T09:04:42Z created: 2020-09-12T09:04:42Z access_permission:extract_for_accessibility: true Creation-Date: 2020-09-12T09:04:42Z Author: Matthias Krumb, Marie-Luise Frey, Jens Langhanki, Robert Forster, Danuta Kowalczyk, Volker Mailänder, Katharina Landfester and Till Opatz producer: pdfTeX-1.40.18 pdf:docinfo:producer: pdfTeX-1.40.18 pdf:unmappedUnicodeCharsPerPage: 17 Keywords: carbohydrates; glycodendrons; dendritic cells; nanocapsules; cell targeting access_permission:modify_annotations: true dc:creator: Matthias Krumb, Marie-Luise Frey, Jens Langhanki, Robert Forster, Danuta Kowalczyk, Volker Mailänder, Katharina Landfester and Till Opatz dcterms:created: 2020-09-12T09:04:42Z Last-Modified: 2020-09-12T09:04:42Z dcterms:modified: 2020-09-12T09:04:42Z title: Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells Last-Save-Date: 2020-09-12T09:04:42Z pdf:docinfo:keywords: carbohydrates; glycodendrons; dendritic cells; nanocapsules; cell targeting pdf:docinfo:modified: 2020-09-12T09:04:42Z meta:save-date: 2020-09-12T09:04:42Z pdf:docinfo:custom:PTEX.Fullbanner: This is pdfTeX, Version 3.14159265-2.6-1.40.18 (TeX Live 2017/W32TeX) kpathsea version 6.2.3 Content-Type: application/pdf X-Parsed-By: org.apache.tika.parser.DefaultParser creator: Matthias Krumb, Marie-Luise Frey, Jens Langhanki, Robert Forster, Danuta Kowalczyk, Volker Mailänder, Katharina Landfester and Till Opatz dc:subject: carbohydrates; glycodendrons; dendritic cells; nanocapsules; cell targeting access_permission:assemble_document: true xmpTPg:NPages: 13 pdf:charsPerPage: 2955 access_permission:extract_content: true access_permission:can_print: true pdf:docinfo:trapped: False meta:keyword: carbohydrates; glycodendrons; dendritic cells; nanocapsules; cell targeting access_permission:can_modify: true pdf:docinfo:created: 2020-09-12T09:04:42Z