Genetic diversity of HLA system in two populations from Michoacán, Mexico: 
Morelia and rural Michoacán

Ballesteros-Romero, Mónica; Barquera, Rodrigo; Rodríguez-López, Marla Estefanía; Hernández-Zaragoza, Diana Iraíz; Goné-Vázquez, Isis; Clayton, Stephen; Arrieta-Bolaños, Esteban; Escobedo-Ruíz, Araceli; Pantoja-Torres, Jorge Arturo; García-Arias, Víctor Eduardo; Arellano-Prado, Francia Paulina; Bravo-Acevedo, Alicia; de Sánchez-Fernández, María Guadalupe Jesús; Sandoval-Sandoval, Mario J.; Gómez-Navarro, Benjamín; Zúñiga, Joaquín; Yunis, Edmond J.; Bekker-Méndez, Carolina; Granados, Julio; Acuña-Alonzo, Víctor

doi:10.1016/j.humimm.2019.05.017

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Genetic diversity of HLA system in two populations from Michoacán, Mexico: Morelia and rural Michoacán

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Barquera, Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton, Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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引用

Ballesteros-Romero, M., Barquera, R., Rodríguez-López, M. E., Hernández-Zaragoza, D. I., Goné-Vázquez, I., Clayton, S., Arrieta-Bolaños, E., Escobedo-Ruíz, A., Pantoja-Torres, J. A., García-Arias, V. E., Arellano-Prado, F. P., Bravo-Acevedo, A., de Sánchez-Fernández, M. G. J., Sandoval-Sandoval, M. J., Gómez-Navarro, B., Zúñiga, J., Yunis, E. J., Bekker-Méndez, C., Granados, J., & Acuña-Alonzo, V. (2020). Genetic diversity of HLA system in two populations from Michoacán, Mexico: Morelia and rural Michoacán. Human Immunology, 81(9), 506-509. doi:10.1016/j.humimm.2019.05.017.

引用: https://hdl.handle.net/21.11116/0000-0007-2F31-E

要旨

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 498 Mexicans from the state of Michoacán living in the city of Morelia (N = 150) and rural communities (N = 348), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Michoacán include 12 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Michoacán are Native American (48.79 ± 1.44) and European (43.10 ± 0.86), while African genetic component is less apparent (8.11 ± 0.85). Our findings add to the growing knowledge on the population genetics of Western Mexico and provide new HLA data on populations from Michoacán.