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Journal Article

Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos

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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons189331

Immel,  Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Ortega-Yáñez, A., Barquera, R., Curiel-Giles, L., Martínez-Álvarez, J. C., Macías-Medrano, R. M., Arrieta-Bolaños, E., et al. (2020). Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos. Human Immunology, 81(9), 557-559. doi:10.1016/j.humimm.2019.07.289.


Cite as: https://hdl.handle.net/21.11116/0000-0007-3001-1
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 112 Mexicans from the state of Morelos living in the city of Cuernavaca (N = 82) and rural communities (N = 30), to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes in Morelos include seven Native American, one European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in Morelos are Native American (60.43 ± 2.22 by ML; 53.57 of Native American haplotypes) and European (39.58 ± 3.70 by ML; 27.68 of European haplotypes), and a virtually absent African genetic component (0.00 ± 4.93 by ML; but 11.16 of African haplotypes).