Genetic diversity of HLA system in three populations from Guanajuato, Mexico: 
Guanajuato City, León and rural Guanajuato

Pantoja-Torres, Jorge Arturo; Barquera, Rodrigo; Ballesteros-Romero, Mónica; Bravo-Acevedo, Alicia; Arrieta-Bolaños, Esteban; Montiel-Hernández, Gustavo Daniel; Clayton, Stephen; Rodríguez-Rodríguez, Lidia Iris; Hernández-Zaragoza, Diana Iraíz; Goné-Vázquez, Isis; Escobedo-Ruíz, Araceli; García-Arias, Víctor Eduardo; Arellano-Prado, Francia Paulina; Rodríguez-López, Marla Estefanía; de Sánchez-Fernández, María Guadalupe Jesús; Sandoval-Sandoval, Mario J.; Gómez-Navarro, Benjamín; Zúñiga, Joaquín; Yunis, Edmond J.; Bekker-Méndez, Carolina; Granados, Julio

doi:10.1016/j.humimm.2019.06.002

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Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, León and rural Guanajuato

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Barquera, Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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引用

Pantoja-Torres, J. A., Barquera, R., Ballesteros-Romero, M., Bravo-Acevedo, A., Arrieta-Bolaños, E., Montiel-Hernández, G. D., Clayton, S., Rodríguez-Rodríguez, L. I., Hernández-Zaragoza, D. I., Goné-Vázquez, I., Escobedo-Ruíz, A., García-Arias, V. E., Arellano-Prado, F. P., Rodríguez-López, M. E., de Sánchez-Fernández, M. G. J., Sandoval-Sandoval, M. J., Gómez-Navarro, B., Zúñiga, J., Yunis, E. J., Bekker-Méndez, C., & Granados, J. (2020). Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, León and rural Guanajuato. Human Immunology, 81(9), 510-512. doi:10.1016/j.humimm.2019.06.002.

引用: https://hdl.handle.net/21.11116/0000-0007-3009-9

要旨

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 262 Mexicans from the state of Guanajuato living in the cities of Guanajuato (N = 78), León (N = 22) and rural communities (N = 162), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Guanajuato include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guanajuato are Native American (50.64 ± 2.11 by ML, 43.35 of Native American haplotypes) and European (44.14 ± 1.14 by ML; 39.35 of European haplotypes), while African genetic component is less apparent (5.22 ± 2.08 by ML; 8.36 of African haplotypes).