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Journal Article

Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping

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Kirilina,  Evgeniya
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany;

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Helbling,  Saskia
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Pine,  Kerrin
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Dinse,  Juliane
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Trampel,  Robert
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Geyer,  Stefan
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Bazin,  Pierre-Louis
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, Germany;

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Weiskopf,  Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany;
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom;

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Kirilina_2020.pdf
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Citation

Kirilina, E., Helbling, S., Morawski, M., Pine, K., Reimann, K., Jankuhn, S., et al. (2020). Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping. Science Advances, 6(41): eaaz9281. doi:10.1126/sciadv.aaz9281.


Cite as: https://hdl.handle.net/21.11116/0000-0007-328B-4
Abstract
Superficial white matter (SWM) contains the most cortico-cortical white matter connections in the human brain encompassing the short U-shaped association fibers. Despite its importance for brain connectivity, very little is known about SWM in humans, mainly due to the lack of noninvasive imaging methods. Here, we lay the groundwork for systematic in vivo SWM mapping using ultrahigh resolution 7 T magnetic resonance imaging. Using biophysical modeling informed by quantitative ion beam microscopy on postmortem brain tissue, we demonstrate that MR contrast in SWM is driven by iron and can be linked to the microscopic iron distribution. Higher SWM iron concentrations were observed in U-fiber-rich frontal, temporal, and parietal areas, potentially reflecting high fiber density or late myelination in these areas. Our SWM mapping approach provides the foundation for systematic studies of interindividual differences, plasticity, and pathologies of this crucial structure for cortico-cortical connectivity in humans.