Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the 
emergence of Hematopoietic Stem and Progenitor Cells

Lefkopoulos, Stylianos; Polyzou, Aikaterini; Derecka, Marta; Bergo, Veronica; Clapes, Thomas; Cauchy, Pierre; Jerez-Longres, Carolina; Onishi-Seebacher, Megumi; Yin, Na; Martagon-Calderón, Natalia-Adriana; Potts, Kathryn S.; Klaeylé, Lhéanna; Liu, Feng; Bowman, Teresa V.; Jenuwein, Thomas; Mione, Maria Caterina; Trompouki, Eirini

doi:10.1016/j.immuni.2020.10.007

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the emergence of Hematopoietic Stem and Progenitor Cells

MPG-Autoren

Lefkopoulos, Stylianos
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Polyzou, Aikaterini
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Derecka, Marta
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Bergo, Veronica
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Clapes, Thomas
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons204283

Cauchy, Pierre
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Jerez-Longres, Carolina
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Yin, Na
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Martagon-Calderón, Natalia-Adriana
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Klaeylé, Lhéanna
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons191130

Jenuwein, Thomas
Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons241707

Trompouki, Eirini
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Externe Ressourcen

https://www.sciencedirect.com/science/article/abs/pii/S1074761320304489?via%3Dihub
(Verlagsversion)

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Es sind keine frei zugänglichen Volltexte in PuRe verfügbar

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Lefkopoulos, S., Polyzou, A., Derecka, M., Bergo, V., Clapes, T., Cauchy, P., et al. (2020). Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the emergence of Hematopoietic Stem and Progenitor Cells. Immunity, 53, 934-951. doi:10.1016/j.immuni.2020.10.007.

Zitierlink: https://hdl.handle.net/21.11116/0000-0007-672D-4

Zusammenfassung

Inflammatory signaling is required for hematopoietic stem and progenitor cell (HSPC) development. Here, we studied the involvement of RIG-I-like receptors (RLRs) in HSPC formation. Rig-I or Mda5 deficiency impaired, while Lgp2 deficiency enhanced, HSPC emergence in zebrafish embryos. Rig-I or Mda5 deficiency reduced HSPC numbers by inhibiting inflammatory signals that were in turn enhanced in Lgp2 deficient embryos. Simultaneous reduction of Lgp2 and either Rig-I or Mda5 rescued inflammatory signals and HSPC numbers. Modulating the expression of the signaling mediator Traf6 in RLR deficient embryos restored HSPC numbers. Repetitive element transcripts could be detected in hemogenic endothelial cells and HSPCs, suggesting a role as RLR ligands. Indeed, ectopic expression of repetitive elements enhanced HSPC formation in wild-type, but not in Rig-I or Mda5 deficient embryos. Manipulation of RLR expression in mouse fetal liver HSPCs indicated functional conservation among species. Thus, repetitive elements transcribed during development drive RLR-mediated inflammatory signals that regulate HSPC formation.