Combining radial and continuous flow synthesis to optimize and scale-up the 
production of medicines

Guidi, Mara; Moon, Soo-Yeon; Anghileri, Lucia; Cambié, Dario; Seeberger, Peter H.; Gilmore, Kerry

doi:10.1039/D0RE00445F

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines

MPS-Authors

/persons/resource/persons246266

Guidi, Mara
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons225482

Moon, Soo-Yeon
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons255640

Anghileri, Lucia
Dario Cambié, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons251284

Cambié, Dario
Dario Cambié, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121849

Seeberger, Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons127138

Gilmore, Kerry
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

Article.pdf
(出版社版), 2MB

付随資料 (公開)

There is no public supplementary material available

引用

Guidi, M., Moon, S.-Y., Anghileri, L., Cambié, D., Seeberger, P. H., & Gilmore, K. (2021). Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines. Reaction Chemistry & Engineering, 6(2), 220-224. doi:10.1039/D0RE00445F.

引用: https://hdl.handle.net/21.11116/0000-0007-AC26-D

要旨

Current drug production in batch cannot adapt rapidly to market demands,} evidenced by recent shortages in many markets globally of essential medicines. Flow chemistry is a valuable tool for on-demand production of active pharmaceutical ingredients (APIs). Here{,} we reveal a new concept to develop and produce APIs{,} where an automated synthesizer that works with discrete volumes of solutions is employed at the discovery stage to identify the optimal synthetic route and conditions before a commercially available continuous flow system is used for scale-up. This concept is illustrated by the synthesis of nifedipine and paracetamol{,} in short supply in Germany during the COVID-19 pandemic{, and the local anesthetic lidocaine.