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Journal Article

The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

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Dikic,  Ivan       
Max Planck Fellow Group ER remodelling Group, Prof. Ivan Đikić, Max Planck Institute of Biophysics, Max Planck Society;
Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany;
Institute of Biochemistry 2, Faculty of Medicine, Goethe Uiversty Frankfurt, Frankfurt, Germany;

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Citation

Wells, C. I., Al-Ali, H., Andrews, D. M., Asquith, C. R. M., Axtman, A. D., Dikic, I., et al. (2021). The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. International Journal of Molecular Sciences, 22(2): 566. doi:10.3390/ijms22020566.


Cite as: https://hdl.handle.net/21.11116/0000-0007-AD19-B
Abstract
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.