Lateral mobility of proteins and lipids in the red cell membrane and the 
activation of adenylate cyclase by beta-adrenergic receptors

Peters, Reiner

doi:10.1016/0014-5793(88)81290-0

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Lateral mobility of proteins and lipids in the red cell membrane and the activation of adenylate cyclase by beta-adrenergic receptors

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Peters, Reiner
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Peters, R. (1988). Lateral mobility of proteins and lipids in the red cell membrane and the activation of adenylate cyclase by beta-adrenergic receptors. FEBS Letters, 2234(1), 1-7. doi:10.1016/0014-5793(88)81290-0.

Cite as: https://hdl.handle.net/21.11116/0000-0008-1A4B-8

Abstract

Models of beta-adrenergic signal transduction in red blood cell membranes frequently assume that at least one of the membrane-bound components is laterally mobile and distributes the hormonal signal in the membrane plane. However, direct measurements reveal that protein lateral mobility in the red cell membrane is severely restricted. Furthermore, the spectrin-actin compartmentalizes the cytoplasmic face of the red cell membrane into a regular array of small elementary areas. These considerations support models in which the beta-adrenergic signal is spread in the membrane plane by a molecule which has binding sites on the membrane but diffuses in the aqueous compartment.