Sensitivity and resolution improvement for in-vivo magnetic resonance current 
density imaging (MRCDI) of the human brain

Goeksu, C; Scheffler, K; Gregersen, F; Eroğlu, HH; Heule, R; Siebner, HR; Hanson, LG; Thielscher, A

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Sensitivity and resolution improvement for in-vivo magnetic resonance current density imaging (MRCDI) of the human brain

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Goeksu, C
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler, K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Heule, R
Institutional Guests, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.ismrm.org/21/program-files/D-45.htm
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引用

Goeksu, C., Scheffler, K., Gregersen, F., Eroğlu, H., Heule, R., Siebner, H., Hanson, L., & Thielscher, A. (2021). Sensitivity and resolution improvement for in-vivo magnetic resonance current density imaging (MRCDI) of the human brain. Poster presented at 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).

引用: https://hdl.handle.net/21.11116/0000-0008-86D4-1

要旨

Effective use of transcranial electrical stimulation (TES) in clinical and neuroscience applications requires the exact knowledge of TES currents. MRCDI uses MRI to measure the TES-induced magnetic fields for estimating the underlying current flow distributions. Their accuracy highly depends on the sensitivity and spatial resolution of the MR measurements. Here, we propose an advanced gradient-echo-based MRCDI method utilizing an optimized spoiling, acquisition-weighting, and navigators to achieve a noise sensitivity of 84pT at 2×2×3mm3 resolution for a total scan time of less than five minutes. We test the method's performance by phantom and human in-vivo experiments for two TES injection profiles.