Variation of microRNA expression in the human placenta driven by population 
identity and sex of the newborn

Guo, Song; Huang, Shuyun; Jiang, Xi; Hu, Haiyang; Han, Dingding; Moreno, Carlos S.; Fairbrother, Genevieve L.; hughes, David A.; Stoneking, Mark; Khaitovich, Philipp

doi:10.1186/s12864-021-07542-0

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Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn

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Stoneking, Mark
Human Population History, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Citation

Guo, S., Huang, S., Jiang, X., Hu, H., Han, D., Moreno, C. S., et al. (2021). Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn. BMC Genomics, 22: 286. doi:10.1186/s12864-021-07542-0.

Cite as: https://hdl.handle.net/21.11116/0000-0008-8704-B

Abstract

Analysis of lymphocyte cell lines revealed substantial differences in the expression of mRNA and microRNA (miRNA) among human populations. The extent of such population-associated differences in actual human tissues remains largely unexplored. The placenta is one of the few solid human tissues that can be collected in substantial numbers in a controlled manner, enabling quantitative analysis of transient biomolecules such as RNA transcripts. Here, we analyzed microRNA (miRNA) expression in human placental samples derived from 36 individuals representing four genetically distinct human populations: African Americans, European Americans, South Asians, and East Asians. All samples were collected at the same hospital following a unified protocol, thus minimizing potential biases that might influence the results.