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Protein condensates as aging Maxwell fluids.

MPS-Authors
/persons/resource/persons189545

Jawerth,  Louise
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons222397

Wang,  Jie
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219166

Franzmann,  Titus
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219595

Ruer,  Martine
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219606

Saha,  Shambaditya
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons104436

Mahamid,  Julia
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219253

Hyman,  Anthony
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons145744

Jülicher,  Frank
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Jawerth, L., Fischer-Friedrich, E., Saha, S., Wang, J., Franzmann, T., Zhang, X., et al. (2020). Protein condensates as aging Maxwell fluids. Science (New York, N.Y.), 370(6522), 1317-1323. doi:10.1126/science.aaw4951.


Cite as: https://hdl.handle.net/21.11116/0000-0008-A329-2
Abstract
Protein condensates are complex fluids that can change their material properties with time. However, an appropriate rheological description of these fluids remains missing. We characterize the time-dependent material properties of in vitro protein condensates using laser tweezer-based active and microbead-based passive rheology. For different proteins, the condensates behave at all ages as viscoelastic Maxwell fluids. Their viscosity strongly increases with age while their elastic modulus varies weakly. No significant differences in structure were seen by electron microscopy at early and late ages. We conclude that protein condensates can be soft glassy materials that we call Maxwell glasses with age-dependent material properties. We discuss possible advantages of glassy behavior for modulation of cellular biochemistry.