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13C-Glucose Labeling Effects measured in the Occipital Lobe and the Frontal Cortex using short TE 1H MC-semiLASER SVS at 9.4T

MPS-Authors
/persons/resource/persons215132

Ziegs,  T
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons215104

Dorst,  J
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84402

Henning,  A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.ismrm.org/21/program-files/D-129.htm
(Abstract)

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Citation

Ziegs, T., Dorst, J., & Henning, A. (2021). 13C-Glucose Labeling Effects measured in the Occipital Lobe and the Frontal Cortex using short TE 1H MC-semiLASER SVS at 9.4T. Poster presented at 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).


Cite as: https://hdl.handle.net/21.11116/0000-0008-EF2A-D
Abstract
Glutamate related metabolism can be measured considering the 13C labeling effects from an administered 13C labeled substrate by short TE 1H MRS spectra without the need for 13C channels, RF coils or scan software as required for direct 13C MRS or 13C edited 1H observed MRS. In this work, the labeling effects were followed in the frontal cortex and the occipital lobe using a short TE 1H MC-semiLASER sequence at 9.4T in healthy volunteers after oral intake of [13C-1]glucose. The spectral time series acquired show obvious 13C labelling related changes in the 1H observed Glu and Gln spectral pattern.