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Preprint

Characterizing pupil dynamics coupling to brain state fluctuation based on lateral hypothalamic activity

MPG-Autoren
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Takahashi,  K
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Sobczak,  F
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen

https://www.biorxiv.org/content/10.1101/2021.09.22.461385v1.full.pdf
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Zitation

Takahashi, K., Sobczak, F., Pais-Roldán, P., & Yu, X. (submitted). Characterizing pupil dynamics coupling to brain state fluctuation based on lateral hypothalamic activity.


Zitierlink: https://hdl.handle.net/21.11116/0000-0009-430D-E
Zusammenfassung
Pupil dynamics presents varied correlation features with brain activity under different vigilant levels. The modulation of brain state changes can arise from the lateral hypothalamus (LH), where diverse neuronal cell types contribute to arousal regulation in opposite directions via the anterior cingulate cortex (ACC). However, the relationship of the LH and pupil dynamics has seldom been investigated. Here, we performed local field potential (LFP) recordings at the LH and ACC, and the whole brain fMRI with simultaneous fiber photometry Ca2+ recording in the ACC, to evaluate their correlation with brain state-dependent pupil dynamics. Both LFP and functional MRI (fMRI) data showed opposite correlation features to pupil dynamics, demonstrating an LH activity-dependent manner. Our results demonstrate that the correlation of pupil dynamics with ACC LFP and whole-brain fMRI signals depends on LH activity, indicating a role of the latter in brain state regulation.