A synthetic morphogenic perceptory cell

Gavriljuk, Konstantin; Ghasemalizadeh, Farid; Scocozza, Bruno; Nandan, Akhilesh P.; Seidel, Hans; Schmick, Malte; Koseska, Aneta; Bastiaens, Philippe I. H.

doi:10.1101/481887

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A synthetic morphogenic perceptory cell

MPS-Authors

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Gavriljuk, Konstantin
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Ghasemalizadeh, Farid
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons238221

Scocozza, Bruno
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons238223

Nandan, Akhilesh P.
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons238225

Seidel, Hans
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons118360

Schmick, Malte
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons118347

Koseska, Aneta
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;
Lise Meitner Group Cellular Computations and Learning, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons98677

Bastiaens, Philippe I. H.
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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https://www.biorxiv.org/content/10.1101/481887v1
(Preprint)

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Citation

Gavriljuk, K., Ghasemalizadeh, F., Scocozza, B., Nandan, A. P., Seidel, H., Schmick, M., et al. (2018). A synthetic morphogenic perceptory cell. bioRxiv: the preprint server for biology, 1-37. doi:10.1101/481887.

Cite as: https://hdl.handle.net/21.11116/0000-0009-5161-E

Abstract

We reconstituted a Synthetic Morphogenic Perceptory System (SynMPS) by encapsulating a dynamic cytoskeletal microtubule (MT)-aster together with a light-actuated signaling system in a liposome. SynMPS responds to light with self-organized morphological state transitions that manifest as self-amplifying membrane deformations generated by the MT-aster recursively interacting with the signaling system. We demonstrate that the perception and response to external light pattern stimuli are shaped by prior exposures and the ensuing morphological states. The interdependence between cytoskeletal dynamics, membrane shape, and signaling thus generated a minimal out-of-equilibrium ‘life-like’ system that mimics context dependent morphological responses of cells to external cues.