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Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses

MPG-Autoren
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Stephani,  Tilman
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Hodapp,  Alice
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons213898

Jamshidi Idaji,  Mina
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Machine Learning Group, TU Berlin, Germany;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Nikulin,  Vadim V.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Institute of Cognitive Neuroscience, National Research University Higher School of Economics, Moscow, Russia;

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Zitation

Stephani, T., Hodapp, A., Jamshidi Idaji, M., Villringer, A., & Nikulin, V. V. (2021). Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses. eLife, 10: e67838. doi:10.7554/eLife.67838.


Zitierlink: https://hdl.handle.net/21.11116/0000-0009-5848-4
Zusammenfassung
Perception of sensory information is determined by stimulus features (e.g., intensity) and instantaneous neural states (e.g., excitability). Commonly, it is assumed that both are reflected similarly in evoked brain potentials, that is, larger amplitudes are associated with a stronger percept of a stimulus. We tested this assumption in a somatosensory discrimination task in humans, simultaneously assessing (i) single-trial excitatory post-synaptic currents inferred from short-latency somatosensory evoked potentials (SEPs), (ii) pre-stimulus alpha oscillations (8-13 Hz), and (iii) peripheral nerve measures. Fluctuations of neural excitability shaped the perceived stimulus intensity already during the very first cortical response (at ~20 ms) yet demonstrating opposite neural signatures as compared to the effect of presented stimulus intensity. We reconcile this discrepancy via a common framework based on the modulation of electro-chemical membrane gradients linking neural states and responses, which calls for reconsidering conventional interpretations of brain potential magnitudes in stimulus intensity encoding.