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pdf:docinfo:title: Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of Viruses
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Keywords: modified heparin; magnesium chloride; antiviral; HSV-1; adenovirus; SARS-CoV-2; NMR
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subject: Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized and primary cells. Nuclear magnetic resonance analyses revealed a conformational change of heparin when complexed with magnesium. To broadly explore this discovery, we tested the antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the replication of HSV-1 was even further decreased compared to aciclovir. Moreover, we investigated the antiviral effect against the new severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and measured a 55-fold decreased viral load in the supernatant of infected cells associated with a 38-fold decrease in virus growth. The advantage of our modified heparin is an increased antiviral effect compared to regular heparin.
dc:creator: Kemal Mese, Oskar Bunz, Wolfram Volkwein, Sahithya P. B. Vemulapalli, Wenli Zhang, Sebastian Schellhorn, Kristin Heenemann, Antje Rueckner, Andreas Sing, Thomas W. Vahlenkamp, Anna-Lena Severing, Jian Gao, Malik Aydin, Dominik Jung, Hagen S. Bachmann, Kurt S. Zänker, Ulrich Busch, Armin Baiker, Christian Griesinger and Anja Ehrhardt
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title: Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of Viruses
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pdf:docinfo:keywords: modified heparin; magnesium chloride; antiviral; HSV-1; adenovirus; SARS-CoV-2; NMR
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dc:title: Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of Viruses
modified: 2021-09-18T08:52:02Z
cp:subject: Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized and primary cells. Nuclear magnetic resonance analyses revealed a conformational change of heparin when complexed with magnesium. To broadly explore this discovery, we tested the antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the replication of HSV-1 was even further decreased compared to aciclovir. Moreover, we investigated the antiviral effect against the new severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and measured a 55-fold decreased viral load in the supernatant of infected cells associated with a 38-fold decrease in virus growth. The advantage of our modified heparin is an increased antiviral effect compared to regular heparin.
pdf:docinfo:subject: Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized and primary cells. Nuclear magnetic resonance analyses revealed a conformational change of heparin when complexed with magnesium. To broadly explore this discovery, we tested the antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the replication of HSV-1 was even further decreased compared to aciclovir. Moreover, we investigated the antiviral effect against the new severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and measured a 55-fold decreased viral load in the supernatant of infected cells associated with a 38-fold decrease in virus growth. The advantage of our modified heparin is an increased antiviral effect compared to regular heparin.
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pdf:docinfo:creator: Kemal Mese, Oskar Bunz, Wolfram Volkwein, Sahithya P. B. Vemulapalli, Wenli Zhang, Sebastian Schellhorn, Kristin Heenemann, Antje Rueckner, Andreas Sing, Thomas W. Vahlenkamp, Anna-Lena Severing, Jian Gao, Malik Aydin, Dominik Jung, Hagen S. Bachmann, Kurt S. Zänker, Ulrich Busch, Armin Baiker, Christian Griesinger and Anja Ehrhardt
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creator: Kemal Mese, Oskar Bunz, Wolfram Volkwein, Sahithya P. B. Vemulapalli, Wenli Zhang, Sebastian Schellhorn, Kristin Heenemann, Antje Rueckner, Andreas Sing, Thomas W. Vahlenkamp, Anna-Lena Severing, Jian Gao, Malik Aydin, Dominik Jung, Hagen S. Bachmann, Kurt S. Zänker, Ulrich Busch, Armin Baiker, Christian Griesinger and Anja Ehrhardt
meta:author: Kemal Mese, Oskar Bunz, Wolfram Volkwein, Sahithya P. B. Vemulapalli, Wenli Zhang, Sebastian Schellhorn, Kristin Heenemann, Antje Rueckner, Andreas Sing, Thomas W. Vahlenkamp, Anna-Lena Severing, Jian Gao, Malik Aydin, Dominik Jung, Hagen S. Bachmann, Kurt S. Zänker, Ulrich Busch, Armin Baiker, Christian Griesinger and Anja Ehrhardt
dc:subject: modified heparin; magnesium chloride; antiviral; HSV-1; adenovirus; SARS-CoV-2; NMR
meta:creation-date: 2021-09-18T02:15:04Z
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meta:keyword: modified heparin; magnesium chloride; antiviral; HSV-1; adenovirus; SARS-CoV-2; NMR
Author: Kemal Mese, Oskar Bunz, Wolfram Volkwein, Sahithya P. B. Vemulapalli, Wenli Zhang, Sebastian Schellhorn, Kristin Heenemann, Antje Rueckner, Andreas Sing, Thomas W. Vahlenkamp, Anna-Lena Severing, Jian Gao, Malik Aydin, Dominik Jung, Hagen S. Bachmann, Kurt S. Zänker, Ulrich Busch, Armin Baiker, Christian Griesinger and Anja Ehrhardt
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