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  Cell signaling as a cognitive process

Koseska, A., & Bastiaens, P. I. H. (2017). Cell signaling as a cognitive process. The EMBO Journal, 36(5), 568-582. doi:10.15252/embj.201695383.

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Genre: Zeitschriftenartikel

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 Urheber:
Koseska, Aneta1, 2, Autor                 
Bastiaens, Philippe I. H.1, Autor           
Affiliations:
1Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753288              
2Lise Meitner Group Cellular Computations and Learning, Center of Advanced European Studies and Research (caesar), Max Planck Society, ou_3231412              

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Schlagwörter: cellular fate; intercellular communication; network reconstruction; network topology; protein network dynamics
 Zusammenfassung: Cellular identity as defined through morphology and function emerges from intracellular signaling networks that communicate between cells. Based on recursive interactions within and among these intracellular networks, dynamical solutions in terms of biochemical behavior are generated that can differ from those in isolated cells. In this way, cellular heterogeneity in tissues can be established, implying that cell identity is not intrinsically predetermined by the genetic code but is rather dynamically maintained in a cognitive manner. We address how to experimentally measure the flow of information in intracellular biochemical networks and demonstrate that even simple causality motifs can give rise to rich, context-dependent dynamic behavior. The concept how intercellular communication can result in novel dynamical solutions is applied to provide a contextual perspective on cell differentiation and tumorigenesis.

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Sprache(n): eng - English
 Datum: 2017-03-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.15252/embj.201695383
 Art des Abschluß: -

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Titel: The EMBO Journal
  Kurztitel : EMBO J.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Nature Publishing Group
Seiten: - Band / Heft: 36 (5) Artikelnummer: - Start- / Endseite: 568 - 582 Identifikator: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061_1