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The development of multi - compartmentalised systems for the directed organisation of artificial cells

MPG-Autoren

Kirchhofer,  Tabea
Tom Robinson, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Thesis.pdf
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Zitation

Kirchhofer, T. (2021). The development of multi - compartmentalised systems for the directed organisation of artificial cells. PhD Thesis, Universität, Potsdam.


Zitierlink: https://hdl.handle.net/21.11116/0000-000A-AF9B-3
Zusammenfassung
Membrane contact sites are of particular interest in the field of synthetic biology and biophysics. They are involved in a great variety of cellular functions. They form in between two cellular organelles or an organelle and the plasma membrane in order to establish a communication path for molecule transport or signal transmission.
The development of an artificial membrane system which can mimic membrane contact sites using bottom up synthetic biology was the goal of this research study. For this, a multi - compartmentalised giant unilamellar vesicle (GUV) system was created with the membrane of the outer vesicle mimicking the plasma membrane and the inner GUVs posing as cellular organelles.
In the following steps, three different strategies were used to achieve an internal membrane - membrane adhesion.