Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative MRI 
study in the HypnoLaus cohort

Marchi, Nicola Andrea; Pizzarotti, Beatrice; Solelhac, Geoffroy; Berger, Mathieu; Haba‐Rubio, José; Preisig, Martin; Vollenweider, Peter; Marques‐Vidal, Pedro; Lutti, Antoine; Kherif, Ferath; Heinzer, Raphael; Draganski, Bogdan

doi:10.1111/jsr.13698

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative MRI study in the HypnoLaus cohort

MPS-Authors

/persons/resource/persons19617

Draganski, Bogdan
Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

Marchi_2022.pdf
(出版社版), 2MB

付随資料 (公開)

There is no public supplementary material available

引用

Marchi, N. A., Pizzarotti, B., Solelhac, G., Berger, M., Haba‐Rubio, J., Preisig, M., Vollenweider, P., Marques‐Vidal, P., Lutti, A., Kherif, F., Heinzer, R., & Draganski, B. (2022). Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative MRI study in the HypnoLaus cohort. Journal of Sleep Research, 31(6):. doi:10.1111/jsr.13698.

引用: https://hdl.handle.net/21.11116/0000-000A-BAAD-2

要旨

Obstructive sleep apnea syndrome (OSA) may be a risk factor for Alzheimer's disease. One of the hallmarks of Alzheimer's disease is disturbed iron homeostasis leading to abnormal iron deposition in brain tissue. To date, there is no empirical evidence to support the hypothesis of altered brain iron homeostasis in patients with obstructive sleep apnea as well. Data were analysed from 773 participants in the HypnoLaus study (mean age 55.9 ± 10.3 years) who underwent polysomnography and brain MRI. Cross-sectional associations were tested between OSA parameters and the MRI effective transverse relaxation rate (R2*) - indicative of iron content - in 68 grey matter regions, after adjustment for confounders. The group with severe OSA (apnea-hypopnea index ≥30/h) had higher iron levels in the left superior frontal gyrus (F3,760 = 4.79, p = 0.003), left orbital gyri (F3,760 = 5.13, p = 0.002), right and left middle temporal gyrus (F3,760 = 4.41, p = 0.004 and F3,760 = 13.08, p < 0.001, respectively), left angular gyrus (F3,760 = 6.29, p = 0.001), left supramarginal gyrus (F3,760 = 4.98, p = 0.003), and right cuneus (F3,760 = 7.09, p < 0.001). The parameters of nocturnal hypoxaemia were all consistently associated with higher iron levels. Measures of sleep fragmentation had less consistent associations with iron content. This study provides the first evidence of increased brain iron levels in obstructive sleep apnea. The observed iron changes could reflect underlying neuropathological processes that appear to be driven primarily by hypoxaemic mechanisms.