date: 2022-07-29T10:14:38Z
pdf:unmappedUnicodeCharsPerPage: 0
pdf:PDFVersion: 1.7
pdf:docinfo:title: Higher Loading of Gold Nanoparticles in PAD Mesenchymal-like Stromal Cells Leads to a Decreased Exocytosis
xmp:CreatorTool: LaTeX with hyperref
Keywords: cell therapy; gold nanoparticles; cell labeling
access_permission:modify_annotations: true
access_permission:can_print_degraded: true
subject: Cell therapy is an important new method in medicine and is being used for the treatment of an increasing number of diseases. The challenge here is the precise tracking of cells in the body and their visualization. One method to visualize cells more easily with current methods is their labeling with nanoparticles before injection. However, for a safe and sufficient cell labeling, the nanoparticles need to remain in the cell and not be exocytosed. Here, we test a glucose-PEG-coated gold nanoparticle for the use of such a cell labeling. To this end, we investigated the nanoparticle exocytosis behavior from PLX-PAD cells, a cell type currently in clinical trials as a potential therapeutic agent. We showed that the amount of exocytosed gold from the cells was influenced by the uptake time and loading amount. This observation will facilitate the safe labeling of cells with nanoparticles in the future and contribute to stem cell therapy research.
dc:creator: Jennifer Oberländer, Rafael Ayerbe, Joan Cabellos, Richard da Costa Marques, Bin Li, Nazende Günday-Türeli, Akif Emre Türeli, Racheli Ofir, Eliran Ish Shalom and Volker Mailänder
dcterms:created: 2022-07-29T10:03:44Z
Last-Modified: 2022-07-29T10:14:38Z
dcterms:modified: 2022-07-29T10:14:38Z
dc:format: application/pdf; version=1.7
title: Higher Loading of Gold Nanoparticles in PAD Mesenchymal-like Stromal Cells Leads to a Decreased Exocytosis
Last-Save-Date: 2022-07-29T10:14:38Z
pdf:docinfo:creator_tool: LaTeX with hyperref
access_permission:fill_in_form: true
pdf:docinfo:keywords: cell therapy; gold nanoparticles; cell labeling
pdf:docinfo:modified: 2022-07-29T10:14:38Z
meta:save-date: 2022-07-29T10:14:38Z
pdf:encrypted: false
dc:title: Higher Loading of Gold Nanoparticles in PAD Mesenchymal-like Stromal Cells Leads to a Decreased Exocytosis
modified: 2022-07-29T10:14:38Z
cp:subject: Cell therapy is an important new method in medicine and is being used for the treatment of an increasing number of diseases. The challenge here is the precise tracking of cells in the body and their visualization. One method to visualize cells more easily with current methods is their labeling with nanoparticles before injection. However, for a safe and sufficient cell labeling, the nanoparticles need to remain in the cell and not be exocytosed. Here, we test a glucose-PEG-coated gold nanoparticle for the use of such a cell labeling. To this end, we investigated the nanoparticle exocytosis behavior from PLX-PAD cells, a cell type currently in clinical trials as a potential therapeutic agent. We showed that the amount of exocytosed gold from the cells was influenced by the uptake time and loading amount. This observation will facilitate the safe labeling of cells with nanoparticles in the future and contribute to stem cell therapy research.
pdf:docinfo:subject: Cell therapy is an important new method in medicine and is being used for the treatment of an increasing number of diseases. The challenge here is the precise tracking of cells in the body and their visualization. One method to visualize cells more easily with current methods is their labeling with nanoparticles before injection. However, for a safe and sufficient cell labeling, the nanoparticles need to remain in the cell and not be exocytosed. Here, we test a glucose-PEG-coated gold nanoparticle for the use of such a cell labeling. To this end, we investigated the nanoparticle exocytosis behavior from PLX-PAD cells, a cell type currently in clinical trials as a potential therapeutic agent. We showed that the amount of exocytosed gold from the cells was influenced by the uptake time and loading amount. This observation will facilitate the safe labeling of cells with nanoparticles in the future and contribute to stem cell therapy research.
Content-Type: application/pdf
pdf:docinfo:creator: Jennifer Oberländer, Rafael Ayerbe, Joan Cabellos, Richard da Costa Marques, Bin Li, Nazende Günday-Türeli, Akif Emre Türeli, Racheli Ofir, Eliran Ish Shalom and Volker Mailänder
X-Parsed-By: org.apache.tika.parser.DefaultParser
creator: Jennifer Oberländer, Rafael Ayerbe, Joan Cabellos, Richard da Costa Marques, Bin Li, Nazende Günday-Türeli, Akif Emre Türeli, Racheli Ofir, Eliran Ish Shalom and Volker Mailänder
meta:author: Jennifer Oberländer, Rafael Ayerbe, Joan Cabellos, Richard da Costa Marques, Bin Li, Nazende Günday-Türeli, Akif Emre Türeli, Racheli Ofir, Eliran Ish Shalom and Volker Mailänder
dc:subject: cell therapy; gold nanoparticles; cell labeling
meta:creation-date: 2022-07-29T10:03:44Z
created: 2022-07-29T10:03:44Z
access_permission:extract_for_accessibility: true
access_permission:assemble_document: true
xmpTPg:NPages: 14
Creation-Date: 2022-07-29T10:03:44Z
pdf:charsPerPage: 3854
access_permission:extract_content: true
access_permission:can_print: true
meta:keyword: cell therapy; gold nanoparticles; cell labeling
Author: Jennifer Oberländer, Rafael Ayerbe, Joan Cabellos, Richard da Costa Marques, Bin Li, Nazende Günday-Türeli, Akif Emre Türeli, Racheli Ofir, Eliran Ish Shalom and Volker Mailänder
producer: pdfTeX-1.40.21
access_permission:can_modify: true
pdf:docinfo:producer: pdfTeX-1.40.21
pdf:docinfo:created: 2022-07-29T10:03:44Z