Swallow tail sign and nigrosome 1: Close but not quite the same

Brammerloh, Malte; Kirilina, Evgeniya; Alkemade, Anneke; Bazin, Pierre-Louis; Jantzen, Caroline; Jäger, Carsten; Herrler, Andreas; Gowland, Penny A.; Forstmann, Birte; Pine, Kerrin; Morawski, Markus; Weiskopf, Nikolaus

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Swallow tail sign and nigrosome 1: Close but not quite the same

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Brammerloh, Malte
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Kirilina, Evgeniya
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Bazin, Pierre-Louis
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Jäger, Carsten
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Pine, Kerrin
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Morawski, Markus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiskopf, Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zitation

Brammerloh, M., Kirilina, E., Alkemade, A., Bazin, P.-L., Jantzen, C., Jäger, C., et al. (2021). Swallow tail sign and nigrosome 1: Close but not quite the same. In Proceedings of the ISMRM & SMRT Annual Meeting & Exhibition.

Zitierlink: https://hdl.handle.net/21.11116/0000-000B-4AD1-6

Zusammenfassung

MRI-based quantification of dopaminergic neurons (DN) and their neuromelanin (NM) in substantia nigra (SN) has great potential to serve as a specific biomarker for neurodegeneration in movement disorders. We used 22-µm-resolution post mortem MR microscopy combined with ion beam microscopy to characterize the magnetic properties of DN. MR microscopy visualized individual DN and provided 3D cellular maps of the entire SN. Static dephasing was determined as main effective transverse relaxation mechanism of DN. We characterized the susceptibility of iron in DN and estimated that the contribution of DN to R2* and QSM may also be detected with in vivo MRI.