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Field dependence of T2* contrast in human substantia nigra

MPG-Autoren
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Brammerloh,  Malte       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Kirilina,  Evgeniya       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Jäger,  Carsten       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Pine,  Kerrin       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Morawski,  Markus       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiskopf,  Nikolaus       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zitation

Brammerloh, M., Kirilina, E., Sibgatulin, R., Herrmann, K.-H., Jäger, C., Pelicon, P., et al. (2022). Field dependence of T2* contrast in human substantia nigra. In Proceedings of the Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting.


Zitierlink: https://hdl.handle.net/21.11116/0000-000B-4AFC-7
Zusammenfassung
MRI holds high promise to diagnose Parkinson’s disease (PD) at clinical field strength B0.
However, it remains unclear which B0 optimizes T2* contrast in substantia nigra, which provides
high diagnostic accuracy. We used quantitative MRI at B0=1.5T-9.4T, MR microscopy, and
histochemistry to characterize the field dependence of the major contributors to R2* (1/T2*):
dopaminergic neurons, ferritin, and myelin. R2* maps were similar at B0=3T-9.4T, and all
contributions scaled approximately linearly with B0. Hence, the contrast mechanisms are similar
across currently available MRI field strengths in vivo, which informs the design of novel PD
biomarkers.