Engineering fatty acid synthases for directed polyketide production

Gajewski, Jan; Buelens, Floris; Serdjukow, Sascha; Janssen, Melanie; Cortina, Nina; Grubmueler, Helmut; Grininger, Martin

doi:10.1038/nchembio.2314

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Engineering fatty acid synthases for directed polyketide production

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Cortina, Nina
Core Facility Metabolomics and small Molecules Mass Spectrometry, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Citation

Gajewski, J., Buelens, F., Serdjukow, S., Janssen, M., Cortina, N., Grubmueler, H., et al. (2017). Engineering fatty acid synthases for directed polyketide production. Nature Chemical Biology, 13(4), 363-365. doi:10.1038/nchembio.2314.

Cite as: https://hdl.handle.net/21.11116/0000-000B-9BC5-8

Abstract

In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.