date: 2024-04-24T14:10:35Z
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pdf:docinfo:title: Evolution and Diversity of TGF-? Pathways are Linked with Novel Developmental and Behavioral Traits
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subject: DOI: 10.1093/molbev/msac252; Molecular Biology and Evolution, 39, 12, 2022-12-05.; Abstract: Transforming growth factor-? (TGF-?) signaling is essential for numerous biologic functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been pivotal in identifying many components. Utilizing a comparative evolutionary approach, we explored TGF-? signaling in nine nematode species and revealed striking variability in TGF-? gene frequency across the lineage. Of the species analyzed, gene duplications in the DAF-7 pathway appear common with the greatest disparity observed in Pristionchus pacificus. Specifically, multiple paralogues of daf-3, daf-4 and daf-7 were detected. To investigate this additional diversity, we induced mutations in 22 TGF-? components and generated corresponding double, triple, and quadruple mutants revealing both conservation and diversification in function. Although the DBL-1 pathway regulating bod
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dc:title: Evolution and Diversity of TGF-? Pathways are Linked with Novel Developmental and Behavioral Traits
modified: 2024-04-24T14:10:35Z
cp:subject: DOI: 10.1093/molbev/msac252; Molecular Biology and Evolution, 39, 12, 2022-12-05.; Abstract: Transforming growth factor-? (TGF-?) signaling is essential for numerous biologic functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been pivotal in identifying many components. Utilizing a comparative evolutionary approach, we explored TGF-? signaling in nine nematode species and revealed striking variability in TGF-? gene frequency across the lineage. Of the species analyzed, gene duplications in the DAF-7 pathway appear common with the greatest disparity observed in Pristionchus pacificus. Specifically, multiple paralogues of daf-3, daf-4 and daf-7 were detected. To investigate this additional diversity, we induced mutations in 22 TGF-? components and generated corresponding double, triple, and quadruple mutants revealing both conservation and diversification in function. Although the DBL-1 pathway regulating bod
pdf:docinfo:subject: DOI: 10.1093/molbev/msac252; Molecular Biology and Evolution, 39, 12, 2022-12-05.; Abstract: Transforming growth factor-? (TGF-?) signaling is essential for numerous biologic functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been pivotal in identifying many components. Utilizing a comparative evolutionary approach, we explored TGF-? signaling in nine nematode species and revealed striking variability in TGF-? gene frequency across the lineage. Of the species analyzed, gene duplications in the DAF-7 pathway appear common with the greatest disparity observed in Pristionchus pacificus. Specifically, multiple paralogues of daf-3, daf-4 and daf-7 were detected. To investigate this additional diversity, we induced mutations in 22 TGF-? components and generated corresponding double, triple, and quadruple mutants revealing both conservation and diversification in function. Although the DBL-1 pathway regulating bod
pdf:docinfo:creator: Wen-Sui Lo
meta:author: Marianne Roca
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Author: Marianne Roca
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dc:description: DOI: 10.1093/molbev/msac252; Molecular Biology and Evolution, 39, 12, 2022-12-05.; Abstract: Transforming growth factor-? (TGF-?) signaling is essential for numerous biologic functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been pivotal in identifying many components. Utilizing a comparative evolutionary approach, we explored TGF-? signaling in nine nematode species and revealed striking variability in TGF-? gene frequency across the lineage. Of the species analyzed, gene duplications in the DAF-7 pathway appear common with the greatest disparity observed in Pristionchus pacificus. Specifically, multiple paralogues of daf-3, daf-4 and daf-7 were detected. To investigate this additional diversity, we induced mutations in 22 TGF-? components and generated corresponding double, triple, and quadruple mutants revealing both conservation and diversification in function. Although the DBL-1 pathway regulating bod
Keywords: TGF-? signaling; Pristionchus pacificus; Caenorhabditis elegans; developmental systems drift; dauer; signaling pathway evolution; phenotypic plasticity; behavior; kin-recognition
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dc:creator: Marianne Roca
description: DOI: 10.1093/molbev/msac252; Molecular Biology and Evolution, 39, 12, 2022-12-05.; Abstract: Transforming growth factor-? (TGF-?) signaling is essential for numerous biologic functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been pivotal in identifying many components. Utilizing a comparative evolutionary approach, we explored TGF-? signaling in nine nematode species and revealed striking variability in TGF-? gene frequency across the lineage. Of the species analyzed, gene duplications in the DAF-7 pathway appear common with the greatest disparity observed in Pristionchus pacificus. Specifically, multiple paralogues of daf-3, daf-4 and daf-7 were detected. To investigate this additional diversity, we induced mutations in 22 TGF-? components and generated corresponding double, triple, and quadruple mutants revealing both conservation and diversification in function. Although the DBL-1 pathway regulating bod
dcterms:created: 2022-12-08T02:06:04Z
Last-Modified: 2024-04-24T14:10:35Z
dcterms:modified: 2024-04-24T14:10:35Z
title: Evolution and Diversity of TGF-? Pathways are Linked with Novel Developmental and Behavioral Traits
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pdf:docinfo:keywords: TGF-? signaling; Pristionchus pacificus; Caenorhabditis elegans; developmental systems drift; dauer; signaling pathway evolution; phenotypic plasticity; behavior; kin-recognition
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dc:subject: TGF-? signaling; Pristionchus pacificus; Caenorhabditis elegans; developmental systems drift; dauer; signaling pathway evolution; phenotypic plasticity; behavior; kin-recognition
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meta:keyword: TGF-? signaling; Pristionchus pacificus; Caenorhabditis elegans; developmental systems drift; dauer; signaling pathway evolution; phenotypic plasticity; behavior; kin-recognition
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pdf:docinfo:created: 2022-12-08T02:06:04Z