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No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease

MPG-Autoren
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Trenado,  Carlos       
Department of Music, Max Planck Institute for Empirical Aesthetics, Max Planck Society;
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University;

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Zitation

Trenado, C., Boschheidgen, M., N’Diaye, K., Schnitzler, A., Mallet, L., & Wojtecki, L. (2023). No effect of subthalamic deep brain stimulation on metacognition in Parkinson’s disease. Scientific Reports, 13: 10. doi:10.1038/s41598-022-26980-8.


Zitierlink: https://hdl.handle.net/21.11116/0000-000C-20AA-0
Zusammenfassung
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a powerful treatment in Parkinson’s disease (PD), which provides a positive effect on motor symptoms although the way it operates on high cognitive processes such as metacognition remains unclear. To address this issue, we recorded electroencephalogram (EEG) of PD patients treated with STN-DBS that performed a reversal learning (RL) paradigm endowed with metacognitive self-assessment. We considered two stimulation conditions, namely DBS-ON (stimulation on) and DBS-OFF (stimulation off), and focused our EEG-analysis on the frontal brain region due to its involvement on high cognitive processes. We found a trend towards a significant difference in RL ability between stimulation conditions. STN-DBS showed no effect on metacognition, although a significant association between accuracy and decision confidence level held for DBS OFF, but not in the case of DBS ON. In summary, our study revealed no significant effect of STN-DBS on RL or metacognition.