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Journal Article

Significant improvement in neuropsychological functions after awake craniotomy in a patient with oligodendroglioma: A case report

MPS-Authors
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Nieberlein,  Laura
Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Hartwigsen,  Gesa       
Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S2214751923000798?via%3Dihub#s0055
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Citation

Thomas, M., Scheer, M., Spindler, K., Nieberlein, L., Hartwigsen, G., Gussew, A., et al. (2023). Significant improvement in neuropsychological functions after awake craniotomy in a patient with oligodendroglioma: A case report. Interdisciplinary Neurosurgery, 33: 101796. doi:10.1016/j.inat.2023.101796.


Cite as: https://hdl.handle.net/21.11116/0000-000D-3ED6-D
Abstract
Objective
The goal of awake craniotomy in glioma patients is sparing of cognitive function. Previous investigations suggest that patients in the postoperative state may reach their preoperative level regarding domain-based criteria. Data on significant postoperative improvement beyond the preoperative level is sparse. This article examines the prospective neuropsychological assessment of a glioma patient who underwent awake craniotomy and has shown functional improvement exceeding preoperative levels.

Methods
A 34-year-old patient with high premorbid cognitive function level who underwent awake craniotomy for left frontal oligodendroglioma was neuropsychologically assessed and took part in a fMRI-examination at 3 different time points.

Results
Preoperative examination revealed severe isolated impairment of working memory, long-term narrative memory in free recall and recognition, and alertness with intact language production and comprehension. After transient global aphasia in the postoperative state, the follow-up examination showed significant improvement in memory and attention exceeding the preoperative level.

Conclusions
Tumor location is an important factor in terms of surgical procedures. Cognitive impairment is, however, not always associated with a specific location. Mechanical pressure of the tumor might have led to the isolated consolidation deficit which fully recovered after tumor removal. Psychological disorders should be taken into account regarding prodromal symptoms of neurooncological diseases.